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    accC biotin carboxylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947761, updated on 3-Dec-2024

    Summary

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    Official Symbol
    accC
    Official Full Name
    biotin carboxylase
    Primary source
    ECOCYC:EG10276
    Locus tag
    b3256
    See related
    ASAP:ABE-0010677
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3243; fabG
    Summary
    Mutations result in negative cooperativity with respect to the substrate bicarbonate. [More information is available at EcoGene: EG10276]. Mutations in the homologous and functionally identical subunit in mammalian proprionyl-CoA carboxylase and 3-methylcrotonyl-CoA carboxylase result in the metabolic deficiency diseases of propionic acidemia or methylcrotonylglycinuria. [More information is available at EcoCyc: EG10276].
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    Genomic context

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    Sequence:
    NC_000913.3 (3405917..3407266)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene biotin carboxyl carrier protein Neighboring gene DUF997 domain-containing protein YhdT Neighboring gene pantothenate:Na(+) symporter Neighboring gene ribosomal protein L11 methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Importance of methionine residues in the enzymatic carboxylation of biotin-containing peptides representing the local biotinyl site of E. coli acetyl-CoA carboxylase. Kondo H, et al. Int J Pept Protein Res, 1984 Jun. PMID 6147321
    2. Kinetic characterization of mutations found in propionic acidemia and methylcrotonylglycinuria: evidence for cooperativity in biotin carboxylase. Sloane V, et al. J Biol Chem, 2004 Apr 16. PMID 14960587
    3. Function of Escherichia coli biotin carboxylase requires catalytic activity of both subunits of the homodimer. Janiyani K, et al. J Biol Chem, 2001 Aug 10. PMID 11390406
    4. Site-directed mutagenesis of ATP binding residues of biotin carboxylase. Insight into the mechanism of catalysis. Sloane V, et al. J Biol Chem, 2001 Jul 6. PMID 11346647
    5. Movement of the biotin carboxylase B-domain as a result of ATP binding. Thoden JB, et al. J Biol Chem, 2000 May 26. PMID 10821865

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. For DnaK, acetyl-CoA carboxylase, biotin carboxylase subunit (AccC) and phosphate acetyltransferase (Pta) we also showed a direct role of PpiB in the functional control of these proteins because it increased the measured enzyme activity of each protein and further interfered with DnaK localization and the correct folding of AccC.
      Title: Cyclophilin PpiB is involved in motility and biofilm formation via its functional association with certain proteins.
    2. This study reports that increased levels of carboxyltransferase (CT) tetramer have no detectable effect on translation of the CT subunit mRNAs.
      Title: Evidence against translational repression by the carboxyltransferase component of Escherichia coli acetyl coenzyme A carboxylase.
    3. It was concluded that biotin carboxylase must be dimeric to fulfill its physiological function.
      Title: Dimerization of the bacterial biotin carboxylase subunit is required for acetyl coenzyme A carboxylase activity in vivo.
    4. analysis of biotin carboxylase in complex with substrates and implications for its catalytic mechanism
      Title: Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism.
    5. N-terminus verified by Edman degradation on complete protein
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    6. Results show that under AccC overexpression conditions AccB is underbiotinylated.
      Title: Coordinate expression of the acetyl coenzyme A carboxylase genes, accB and accC, is necessary for normal regulation of biotin synthesis in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables biotin carboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables biotin carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in malonyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in malonyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of acetyl-CoA carboxylase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    biotin carboxylase
    NP_417722.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3405917..3407266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417722.1 biotin carboxylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417722.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A418GHT7
      Conserved Domains (1) summary
      PRK08591
      Location:1 → 449
      PRK08591; acetyl-CoA carboxylase biotin carboxylase subunit; Validated
    Nucleotide Protein
    Heading Accession and Version

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