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    galM galactose-1-epimerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944943, updated on 3-Dec-2024

    Summary

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    Official Symbol
    galM
    Official Full Name
    galactose-1-epimerase
    Primary source
    ECOCYC:EG11698
    Locus tag
    b0756
    See related
    ASAP:ABE-0002566
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0745
    Summary
    GalM substrates include D-galactose, D-glucose, L-arabinose, D-xylose, maltose and lactose. [More information is available at EcoGene: EG11698].
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    Genomic context

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    Sequence:
    NC_000913.3 (787797..788837, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive Neighboring gene 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase Neighboring gene galactokinase Neighboring gene galactose-1-phosphate uridylyltransferase Neighboring gene UDP-glucose 4-epimerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Galactose mutarotase: purification, characterization, and investigations of two important histidine residues. Beebe JA, et al. Biochemistry, 1998 Oct 20. PMID 9778377
    2. Protein sequence from downstream of Escherichia coli galK is homologous with galM from other organisms. Maskell D. Mol Microbiol, 1992 Aug. PMID 1406262
    3. [Enzymatically catalyzed mutarotation of aldoses. Studies on aldose-1-epimerase from E. coli]. Wallenfels K, et al. Biochem Z, 1965 Dec 1. PMID 4290293
    4. The enzymatically catalyzed mutarotaton. The mechanism of action of mutarotase (aldose 1-epimerase) from Escherichia coli. Hucho F, et al. Eur J Biochem, 1971 Dec 10. PMID 4945113
    5. [Aldose-1-epimerase (mutarotase) from E. coli. Purification and preliminary molecular characterization]. Wallenfels K, et al. Biochem Z, 1965 Dec 1. PMID 5337146

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aldose 1-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose 1-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldose 1-epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in galactose catabolic process via UDP-galactose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within galactose catabolic process via UDP-galactose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hexose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    galactose-1-epimerase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      787797..788837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415277.1 galactose-1-epimerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415277.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1NGZ3
      Conserved Domains (1) summary
      PRK11055
      Location:7 → 345
      galM; galactose-1-epimerase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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