U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ppsA phosphoenolpyruvate synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946209, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ppsA
    Official Full Name
    phosphoenolpyruvate synthetase
    Primary source
    ECOCYC:EG10759
    Locus tag
    b1702
    See related
    ASAP:ABE-0005678
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1700; pps
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1784734..1787112, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative electron transfer flavoprotein-quinone oxidoreductase YdiS Neighboring gene ferredoxin-like protein YdiT Neighboring gene short chain acyl-CoA synthetase Neighboring gene phosphoenolpyruvate synthetase regulatory protein Neighboring gene 3-deoxy-7-phosphoheptulonate synthase, Trp-sensitive

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. PpsA-mediated alternative pathway to complement RNase E essentiality in Escherichia coli. Tamura M, et al. Arch Microbiol, 2016 Jul. PMID 26883538
    2. Net formation of phosphoenolpyruvate from pyruvate by Escherichia coli. Cooper RA, et al. Biochim Biophys Acta, 1965 Jul 8. PMID 5322808
    3. On the mechanism of ATP cleavage in the phosphoenolpyruvate synthase reaction of Escherichia coli. Berman K, et al. Biochim Biophys Acta, 1967 Jun 13. PMID 4860971
    4. Kinetic competition in vitro between phosphoenolpyruvate synthetase and the pyruvate dehydrogenase complex from Escherichia coli. Chulavatnatol M, et al. J Biol Chem, 1973 Apr 25. PMID 4572512
    5. Phosphoenolpyruvate synthetase from Escherichia coli. Effects of adenylate energy charge and modifier concentrations. Chulavatnatol M, et al. J Biol Chem, 1973 Apr 25. PMID 4572511

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. demonstrate the role of phosphoryl transfer catalyzable by PpsA as a determinant of RNase E essentiality in E. coli.
      Title: PpsA-mediated alternative pathway to complement RNase E essentiality in Escherichia coli.
    2. In the present study, ppsA and tktA genes were overexpressed in genetically engineered Escherichia coli to enhance the availability of two precursor substrates, phosphoenolpyruvate and erythrose-4-phosphate.
      Title: Improved production of tryptophan in genetically engineered Escherichia coli with TktA and PpsA overexpression.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Cloning and nucleotide sequence of the Escherichia coli K-12 ppsA gene, encoding PEP synthase.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pyruvate, water dikinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyruvate, water dikinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyruvate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    phosphoenolpyruvate synthetase
    NP_416217.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1784734..1787112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416217.1 phosphoenolpyruvate synthetase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416217.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2H4TZE7, A0A376M8G6
      Conserved Domains (1) summary
      PRK06464
      Location:6 → 792
      PRK06464; phosphoenolpyruvate synthase; Validated
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.