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    eda KHG/KDPG aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946367, updated on 17-Dec-2024

    Summary

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    Official Symbol
    eda
    Official Full Name
    KHG/KDPG aldolase
    Primary source
    ECOCYC:EG10256
    Locus tag
    b1850
    See related
    ASAP:ABE-0006164
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1851; hga; kdgA; kga
    Summary
    Eda: [More information is available at EcoCyc: EG10256].
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    Genomic context

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    Sequence:
    NC_000913.3 (1932115..1932756, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA damage-inducible protein YebG Neighboring gene phosphoribosylglycinamide formyltransferase 2 Neighboring gene phosphogluconate dehydratase Neighboring gene NADP(+)-dependent glucose-6-phosphate dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for an essential arginine residue in the active site of Escherichia coli 2-keto-4-hydroxyglutarate aldolase. Modification with 1,2-cyclohexanedione. Vlahos CJ, et al. J Biol Chem, 1985 May 10. PMID 3886656
    2. Recovery of respiration following the SOS response of Escherichia coli requires RecA-mediated induction of 2-keto-4-hydroxyglutarate aldolase. Cayrol C, et al. Proc Natl Acad Sci U S A, 1995 Dec 5. PMID 8524853, Free PMC Article
    3. Steady-state kinetics and inhibition studies of the aldol condensation reaction catalyzed by bovine liver and Escherichia coli 2-keto-4-hydroxyglutarate aldolase. Grady SR, et al. Biochemistry, 1981 Apr 28. PMID 7016177
    4. Physical and chemical evidence for the trimeric subunit structure of 2-keto-4-hydroxyglutarate aldolase from Escherichia coli K-12. Wang JK, et al. J Biol Chem, 1981 Feb 25. PMID 7007372
    5. Malyl-CoA formation in the NAD-, CoASH-, and alpha-ketoglutarate dehydrogenase-dependent oxidation of 2-keto-4-hydroxyglutarate. Possible coupled role of this reaction with 2-keto-4-hydroxyglutarate aldolase activity in a pyruvate-catalyzed cyclic oxidation of glyoxylate. Gupta SC, et al. J Biol Chem, 1984 Aug 25. PMID 6381479

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: The complete amino acid sequence and identification of the active-site arginine peptide of Escherichia coli 2-keto-4-hydroxyglutarate aldolase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables (4S)-4-hydroxy-2-oxoglutarate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables (4S)-4-hydroxy-2-oxoglutarate aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables (4S)-4-hydroxy-2-oxoglutarate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables (R,S)-4-hydroxy-2-oxoglutarate aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables (R,S)-4-hydroxy-2-oxoglutarate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-dehydro-3-deoxy-phosphogluconate aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-dehydro-3-deoxy-phosphogluconate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-dehydro-3-deoxy-phosphogluconate aldolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables aldehyde-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxaloacetate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxaloacetate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxo-acid-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Entner-Doudoroff pathway through 6-phosphogluconate EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in Entner-Doudoroff pathway through 6-phosphogluconate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    KHG/KDPG aldolase
    NP_416364.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1932115..1932756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416364.1 KHG/KDPG aldolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416364.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2G5X0, A0A5B9ALR2
      Conserved Domains (1) summary
      PRK05718
      Location:1 → 212
      PRK05718; keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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