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    bioD dethiobiotin synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945387, updated on 17-Dec-2024

    Summary

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    Official Symbol
    bioD
    Official Full Name
    dethiobiotin synthetase
    Primary source
    ECOCYC:EG10120
    Locus tag
    b0778
    See related
    ASAP:ABE-0002650
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0767
    Summary
    False positive lipoprotein prediction, verified amino terminus, Met is cleaved. [More information is available at EcoGene: EG10120]. Dethiobiotin synthetase catalyzes the first ring closure in the biosynthesis of biotin, which is the penultimate step in the biosynthesis pathway. [More information is available at EcoCyc: EG10120].
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    Genomic context

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    Sequence:
    NC_000913.3 (812270..812947)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene adenosylmethionine-8-amino-7-oxononanoate aminotransferase Neighboring gene biotin synthase Neighboring gene 8-amino-7-oxononanoate synthase Neighboring gene malonyl-acyl carrier protein methyltransferase Neighboring gene UvrABC excision nuclease subunit B Neighboring gene putative transferase YbhK

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Snapshot of a phosphorylated substrate intermediate by kinetic crystallography. Käck H, et al. Proc Natl Acad Sci U S A, 1998 May 12. PMID 9576910, Free PMC Article
    2. Crystal structure of an ATP-dependent carboxylase, dethiobiotin synthetase, at 1.65 A resolution. Huang W, et al. Structure, 1994 May 15. PMID 8081756
    3. Sequence and crystallization of Escherichia coli dethiobiotin synthetase, the penultimate enzyme of biotin biosynthesis. Alexeev D, et al. J Mol Biol, 1994 Jan 14. PMID 8289297
    4. Substrate binding and carboxylation by dethiobiotin synthetase--a kinetic and X-ray study. Alexeev D, et al. Structure, 1995 Nov 15. PMID 8591031
    5. Mechanistic implications and family relationships from the structure of dethiobiotin synthetase. Alexeev D, et al. Structure, 1994 Nov 15. PMID 7881906

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Sequence and crystallization of Escherichia coli dethiobiotin synthetase, the penultimate enzyme of biotin biosynthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    dethiobiotin synthetase
    NP_415299.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      812270..812947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415299.1 dethiobiotin synthetase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415299.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3JJA7
      Conserved Domains (1) summary
      COG0132
      Location:1 → 225
      BioD; Dethiobiotin synthetase [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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