hemA glutamyl-tRNA reductase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: hemA
Official Full Name: glutamyl-tRNA reductase
Primary source: ECOCYC:EG10427
Locus tag: b1210
See related: ASAP:ABE-0004064
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK1198; gtrA
Summary: Glutamyl-tRNA reductase catalyzes the first step of porphyrin biosynthesis. [More information is available at EcoCyc: EG10427].
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NC_000913.3 Genomic Context describing neighboring genes

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A novel hemA mutation is responsible for a small-colony-variant phenotype in Escherichia coli.
Title: A novel hemA mutation is responsible for a small-colony-variant phenotype in Escherichia coli.
analysis of glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase complex formation in Escherichia coli during the initial reactions of porphyrin biosynthesis
Title: Complex formation between glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase in Escherichia coli during the initial reactions of porphyrin biosynthesis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables glutamyl-tRNA reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamyl-tRNA reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamyl-tRNA reductase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in porphyrin-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protoporphyrinogen IX biosynthetic process from glutamate	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protoporphyrinogen IX biosynthetic process from glutamate	IDA Inferred from Direct Assay more info	PubMed
involved_in tetrapyrrole biosynthetic process	IEA Inferred from Electronic Annotation more info

NP_415728.1

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