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    pdxH pyridoxine/pyridoxamine 5'-phosphate oxidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946806, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pdxH
    Official Full Name
    pyridoxine/pyridoxamine 5'-phosphate oxidase
    Primary source
    ECOCYC:EG11487
    Locus tag
    b1638
    See related
    ASAP:ABE-0005482
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1634
    Summary
    The pdxH gene codes for a monofunctional flavoprotein enzyme that can accept either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) as substrates. [More information is available at EcoCyc: EG11487].
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    Genomic context

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    Sequence:
    NC_000913.3 (1717351..1718007, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pyridoxal kinase 2 Neighboring gene tyrosine--tRNA ligase Neighboring gene inhibitor of c-type lysozyme, putative lipoprotein Neighboring gene anhydro-N-acetylmuramic acid kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lysine acetylation regulates the activity of Escherichia coli pyridoxine 5'-phosphate oxidase. Gu J, et al. Acta Biochim Biophys Sin (Shanghai), 2017 Feb 6. PMID 28039149
    2. Identification and characterization of the pyridoxal 5'-phosphate allosteric site in Escherichia coli pyridoxine 5'-phosphate oxidase. Barile A, et al. J Biol Chem, 2021 Jan-Jun. PMID 34019876, Free PMC Article
    3. Genetic map position of the pdxH gene in Escherichia coli. Shimizu S, et al. J Bacteriol, 1976 Sep. PMID 783152, Free PMC Article
    4. Purification and characterization of the pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating) from Escherichia coli. Notheis C, et al. Biochim Biophys Acta, 1995 Mar 15. PMID 7696318
    5. Synthesis of Pyridoxine by a Pyridoxal Auxotroph of Escherichia coli. Dempsey WB. J Bacteriol, 1966 Aug. PMID 16562115, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Site-directed mutagenesis analysis indicated that acetylated lysine residues play important roles in the enzymatic activity and enzymatic properties of pyridoxine 5'-phosphate oxidase (EcPNPOx).
      Title: Lysine acetylation regulates the activity of Escherichia coli pyridoxine 5'-phosphate oxidase.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Kinetic limitation and cellular amount of pyridoxine (pyridoxamine) 5'-phosphate oxidase of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphate ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxamine phosphate oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxamine phosphate oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxamine phosphate oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables riboflavin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' pyridoxal 5'-phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organic hydroxy compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyridoxal phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyridoxine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vitamin B6 metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyridoxine/pyridoxamine 5'-phosphate oxidase
    NP_416155.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1717351..1718007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416155.1 pyridoxine/pyridoxamine 5'-phosphate oxidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416155.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AIY8, A0A8S7EG98
      Conserved Domains (1) summary
      PRK05679
      Location:24 → 218
      PRK05679; pyridoxal 5'-phosphate synthase
    Nucleotide Protein
    Heading Accession and Version

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