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    cobU cobinamide-P guanylyltransferase/cobinamide kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946519, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cobU
    Official Full Name
    cobinamide-P guanylyltransferase/cobinamide kinase
    Primary source
    ECOCYC:EG13238
    Locus tag
    b1993
    See related
    ASAP:ABE-0006616
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1988
    Summary
    Escherichia coli K-12, as well as natural isolates, can synthesize cobalamin only when supplied with the intermediate cobinamide . cobU encodes a predicted bifunctional protein complex with cobinamide kinase and cobinamide-P guanylyltransferase activity . [More information is available at EcoCyc: EG13238].
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    Genomic context

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    Sequence:
    NC_000913.3 (2065219..2065764, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene L,D-transpeptidase LdtA Neighboring gene nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Neighboring gene cobalamin 5'-phosphate synthase Neighboring gene pseudo Neighboring gene IS5 family transposase and trans-activator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of coenzyme B12 synthesis among enteric bacteria: evidence for loss and reacquisition of a multigene complex. Lawrence JG, et al. Genetics, 1996 Jan. PMID 8770581, Free PMC Article
    2. Over 1000 genes are involved in the DNA damage response of Escherichia coli. Khil PP, et al. Mol Microbiol, 2002 Apr. PMID 11967071
    3. The cobalamin (coenzyme B12) biosynthetic genes of Escherichia coli. Lawrence JG, et al. J Bacteriol, 1995 Nov. PMID 7592411, Free PMC Article
    4. A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. Itoh T, et al. DNA Res, 1996 Dec 31. PMID 9097040
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosylcobinamide kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cobinamide phosphate guanylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cobinamide phosphate guanylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cobalamin biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in cobalamin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cobinamide-P guanylyltransferase/cobinamide kinase
    NP_416497.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2065219..2065764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416497.1 cobinamide-P guanylyltransferase/cobinamide kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416497.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2Y0YVM8, A0A3P5DQ98
      Conserved Domains (1) summary
      PRK05800
      Location:1 → 181
      cobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Validated
    Nucleotide Protein
    Heading Accession and Version

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