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    grxC reduced glutaredoxin 3 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948132, updated on 3-Dec-2024

    Summary

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    Official Symbol
    grxC
    Official Full Name
    reduced glutaredoxin 3
    Primary source
    ECOCYC:EG12294
    Locus tag
    b3610
    See related
    ASAP:ABE-0011801
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3600; yibM
    Summary
    There at least three glutaredoxins in Escherichia coli. [More information is available at EcoCyc: EG12294].
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    Genomic context

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    Sequence:
    NC_000913.3 (3784191..3784442, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene serine acetyltransferase Neighboring gene glycerol-3-phosphate dehydrogenase Neighboring gene protein export chaperone SecB Neighboring gene putative sulfurtransferase YibN Neighboring gene 2,3-bisphosphoglycerate-independent phosphoglycerate mutase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Determinants of activity in glutaredoxins: an in vitro evolved Grx1-like variant of Escherichia coli Grx3. Elgán TH, et al. Biochem J, 2010 Sep 15. PMID 20604742
    2. Quantifying Escherichia coli glutaredoxin-3 substrate specificity using ligand-induced stability. Elgán TH, et al. J Biol Chem, 2008 Nov 21. PMID 18757366
    3. NMR structure of Escherichia coli glutaredoxin 3-glutathione mixed disulfide complex: implications for the enzymatic mechanism. Nordstrand K, et al. J Mol Biol, 1999 Feb 19. PMID 9973569
    4. The reducing activity of glutaredoxin 3 toward cytoplasmic substrate proteins is restricted by methionine 43. Porat A, et al. Biochemistry, 2007 Mar 20. PMID 17305371, Free PMC Article
    5. Glutaredoxin-3 from Escherichia coli. Amino acid sequence, 1H AND 15N NMR assignments, and structural analysis. Aslund F, et al. J Biol Chem, 1996 Mar 22. PMID 8636094

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest that the Grx1-like activity of the Grx3(M43V/C65Y) mutant may be explained by enhanced intrinsic motion allowing for increased specificity towards larger substrates
      Title: Determinants of activity in glutaredoxins: an in vitro evolved Grx1-like variant of Escherichia coli Grx3.
    2. analysis of Escherichia coli glutaredoxin-3 substrate specificity
      Title: Quantifying Escherichia coli glutaredoxin-3 substrate specificity using ligand-induced stability.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Two additional glutaredoxins exist in Escherichia coli: glutaredoxin 3 is a hydrogen donor for ribonucleotide reductase in a thioredoxin/glutaredoxin 1 double mutant.
    4. Molecular dynamics simulations suggest that Met43Val substitution results in changes in properties of N-terminal cysteine of active site leading to considerably lower pKa. Grx3-Met43Val shows an 11 mV lower redox potential than the wild-type Grx3.
      Title: The reducing activity of glutaredoxin 3 toward cytoplasmic substrate proteins is restricted by methionine 43.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glutathione binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione disulfide oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deoxyribonucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    reduced glutaredoxin 3
    NP_418067.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3784191..3784442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418067.1 reduced glutaredoxin 3 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418067.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A346Y7J1
      Conserved Domains (1) summary
      PRK10638
      Location:1 → 83
      PRK10638; glutaredoxin 3; Provisional
    Nucleotide Protein
    Heading Accession and Version

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