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    msrP protein-L-methionine sulfoxide reductase catalytic subunit MsrP [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946484, updated on 3-Dec-2024

    Summary

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    Official Symbol
    msrP
    Official Full Name
    protein-L-methionine sulfoxide reductase catalytic subunit MsrP
    Primary source
    ECOCYC:G7059
    Locus tag
    b1971
    See related
    ASAP:ABE-0006540
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1967; yedY
    Summary
    YedZY has other in vitro substrates, physiological role unknown; mutant had no growth defect. [More information is available at EcoGene: EG14047]. YedY is a periplasmic molybdoprotein that contains a twin-arginine signal peptide. [More information is available at EcoCyc: G7059].
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    Genomic context

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    Sequence:
    NC_000913.3 (2039478..2040482)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene sensor histidine kinase HprS Neighboring gene DNA-binding transcriptional dual regulator HprR Neighboring gene hydroxyisourate hydrolase/transthyretin-related protein Neighboring gene membrane-bound flavocytochrome MsrQ Neighboring gene metal-binding protein ZinT

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the molybdenum site in YedY, a sulfite oxidase homologue from Escherichia coli. Havelius KG, et al. Inorg Chem, 2011 Feb 7. PMID 21190337
    2. Molybdenum site structure of Escherichia coli YedY, a novel bacterial oxidoreductase. Pushie MJ, et al. Inorg Chem, 2011 Feb 7. PMID 21190336
    3. Evolutionary persistence of the molybdopyranopterin-containing sulfite oxidase protein fold. Workun GJ, et al. Microbiol Mol Biol Rev, 2008 Jun. PMID 18535145, Free PMC Article
    4. Repairing oxidized proteins in the bacterial envelope using respiratory chain electrons. Gennaris A, et al. Nature, 2015 Dec 17. PMID 26641313, Free PMC Article
    5. Molybdenum cofactor-dependent resistance to N-hydroxylated base analogs in Escherichia coli is independent of MobA function. Kozmin SG, et al. Mutat Res, 2007 Jun 1. PMID 17349664, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study investigated the atomic structure of the molybdenum site in YedY by X-ray absorption spectroscopy
      Title: Structure of the molybdenum site in YedY, a sulfite oxidase homologue from Escherichia coli.
    2. The study reports on the structural characterization using X-ray absorption spectroscopy of the molybdenum site of Escherichia coli YedY.
      Title: Molybdenum site structure of Escherichia coli YedY, a novel bacterial oxidoreductase.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Structural and biochemical identification of a novel bacterial oxidoreductase.
    4. YedY is a sulfite oxidase catalytic subunit with a twin arginine leader sequence for export to the periplasm by the Tat translocation system.
      Title: Characterization of an Escherichia coli sulfite oxidase homologue reveals the role of a conserved active site cysteine in assembly and function.
    5. YedY and its many orthologues may represent a new type of membrane-associated bacterial reductase.
      Title: Structural and biochemical identification of a novel bacterial oxidoreductase.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdopterin cofactor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molybdopterin cofactor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on a heme group of donors IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on a sulfur group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hypochlorite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-L-methionine sulfoxide reductase catalytic subunit MsrP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2039478..2040482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416480.1 protein-L-methionine sulfoxide reductase catalytic subunit MsrP [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416480.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376K4H8, A0A8S7EM04
      Conserved Domains (1) summary
      PRK05363
      Location:1 → 334
      PRK05363; protein-methionine-sulfoxide reductase catalytic subunit MsrP
    Nucleotide Protein
    Heading Accession and Version

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