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    wcaF colanic acid biosynthesis acetyltransferase WcaF [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946578, updated on 3-Dec-2024

    Summary

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    Official Symbol
    wcaF
    Official Full Name
    colanic acid biosynthesis acetyltransferase WcaF
    Primary source
    ECOCYC:G7099
    Locus tag
    b2054
    See related
    ASAP:ABE-0006805
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2048
    Summary
    WcaF contains hexapeptide repeats. [More information is available at EcoGene: EG13574]. WcaF is believed to be an acetyltransferase involved in colanic acid synthesis based on sequence similarity and its presence in a putative colanic acid synthesis operon . [More information is available at EcoCyc: G7099].
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    Genomic context

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    Sequence:
    NC_000913.3 (2128340..2128888, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene GDP-L-fucose synthase Neighboring gene GDP-mannose 4,6-dehydratase Neighboring gene GDP-Fuc:2/3-O-Ac-alpha-L-Fuc-(1->3)-alpha-D-Glc-PP-Und alpha-(1,4)-fucosyltransferase Neighboring gene colanic acid polymerase Neighboring gene colanic acid biosynthesis galactosyltransferase WcaC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exopolysaccharide production is required for development of Escherichia coli K-12 biofilm architecture. Danese PN, et al. J Bacteriol, 2000 Jun. PMID 10852895, Free PMC Article
    2. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Whitfield C. Annu Rev Biochem, 2006. PMID 16756484
    3. Development of a biofilm production-deficient Escherichia coli strain as a host for biotechnological applications. Sung BH, et al. Appl Environ Microbiol, 2006 May. PMID 16672475, Free PMC Article
    4. Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli. Hagiwara D, et al. J Bacteriol, 2003 Oct. PMID 13129944, Free PMC Article
    5. Regulating exopolysaccharide gene wcaF allows control of Escherichia coli biofilm formation. Zhang J, et al. Sci Rep, 2018 Sep 3. PMID 30177768, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Putative colonic acid biosynthesis acyl transferase controls Escherichia coli biofilm formation.
      Title: Regulating exopolysaccharide gene wcaF allows control of Escherichia coli biofilm formation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables O-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within colanic acid biosynthetic process IGC
    Inferred from Genomic Context
    more info
    		 PubMed 
    acts_upstream_of_or_within colanic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in slime layer polysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    colanic acid biosynthesis acetyltransferase WcaF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2128340..2128888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416558.1 colanic acid biosynthesis acetyltransferase WcaF [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416558.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7X3Y5
      Conserved Domains (1) summary
      TIGR04008
      Location:1 → 180
      WcaF; colanic acid biosynthesis acetyltransferase WcaF
    Nucleotide Protein
    Heading Accession and Version

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