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    pdeL DNA-binding transcriptional regulator/c-di-GMP phosphodiesterase PdeL [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947459, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pdeL
    Official Full Name
    DNA-binding transcriptional regulator/c-di-GMP phosphodiesterase PdeL
    Primary source
    ECOCYC:EG11236
    Locus tag
    b0315
    See related
    ASAP:ABE-0001086
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0313; yahA
    Summary
    YahA has a C-terminal EAL domain, however, it lacks the GGDEF motif. [More information is available at EcoGene: EG11236]. Purified YahA exhibits c-di-GMP-specific phosphodiesterase activity. [More information is available at EcoCyc: EG11236].
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    Genomic context

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    Sequence:
    NC_000913.3 (332371..333459)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene choline:H(+) symporter Neighboring gene protein YahV Neighboring gene putative LysR-type DNA-binding transcriptional regulator YahB Neighboring gene uncharacterized protein YahC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger cyclic di-GMP. Sundriyal A, et al. J Biol Chem, 2014 Mar 7. PMID 24451384, Free PMC Article
    2. The flagellar sigma factor FliA regulates adhesion and invasion of Crohn disease-associated Escherichia coli via a cyclic dimeric GMP-dependent pathway. Claret L, et al. J Biol Chem, 2007 Nov 16. PMID 17827157
    3. DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli. Lamark T, et al. Mol Microbiol, 1991 May. PMID 1956285
    4. Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli. Reinders A, et al. J Bacteriol, 2016 Feb 1. PMID 26553851, Free PMC Article
    5. Systematic search for the Cra-binding promoters using genomic SELEX system. Shimada T, et al. Genes Cells, 2005 Sep. PMID 16115199

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclic-guanylate-specific phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclic-guanylate-specific phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional regulator/c-di-GMP phosphodiesterase PdeL
    NP_414849.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      332371..333459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414849.1 DNA-binding transcriptional regulator/c-di-GMP phosphodiesterase PdeL [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414849.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3JLS8
      Conserved Domains (2) summary
      cd06170
      Location:26 → 80
      LuxR_C_like; C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many ...
      smart00052
      Location:110 → 350
      EAL; Putative diguanylate phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version

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