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    mhpA 3-(3-hydroxyphenyl)propanoate hydroxylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945197, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mhpA
    Official Full Name
    3-(3-hydroxyphenyl)propanoate hydroxylase
    Primary source
    ECOCYC:M010
    Locus tag
    b0347
    See related
    ASAP:ABE-0001196
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0344
    Summary
    visC, ubiH, ubiF and mhpA are paralogs. [More information is available at EcoGene: EG20273].
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    Genomic context

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    Sequence:
    NC_000913.3 (368611..370275)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor LacI Neighboring gene DNA-binding transcriptional activator MhpR Neighboring gene 3-carboxyethylcatechol 2,3-dioxygenase Neighboring gene 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of the mhp cluster responsible for 3-(3-hydroxyphenyl)propionic acid degradation in Escherichia coli. Torres B, et al. J Biol Chem, 2003 Jul 25. PMID 12748194
    2. Overproduction, purification and properties of 2,3-dihydroxyphenylpropionate 1,2-dioxygenase from Escherichia coli. Bugg TD. Biochim Biophys Acta, 1993 Oct 6. PMID 8399388
    3. Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli. Burlingame R, et al. J Bacteriol, 1983 Jul. PMID 6345502, Free PMC Article
    4. Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation. Burlingame RP, et al. J Bacteriol, 1986 Oct. PMID 3531186, Free PMC Article
    5. The SWISS-PROT protein sequence data bank, recent developments. Bairoch A, et al. Nucleic Acids Res, 1993 Jul 1. PMID 8332529, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-(3-hydroxyphenyl)propionate hydroxylase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables 3-(3-hydroxyphenyl)propionate hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-(3-hydroxyphenyl)propionate hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-(3-hydroxyphenyl)propionate hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3-(3-hydroxy)phenylpropionate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3-(3-hydroxy)phenylpropionate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within 3-(3-hydroxy)phenylpropionate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in 3-phenylpropionate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3-(3-hydroxyphenyl)propanoate hydroxylase
    NP_414881.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      368611..370275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414881.1 3-(3-hydroxyphenyl)propanoate hydroxylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414881.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N3HYP5
      Conserved Domains (1) summary
      PRK06183
      Location:1 → 544
      mhpA; bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase
    Nucleotide Protein
    Heading Accession and Version

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