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    queE putative 7-carboxy-7-deazaguanine synthase QueE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947527, updated on 17-Dec-2024

    Summary

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    Official Symbol
    queE
    Official Full Name
    putative 7-carboxy-7-deazaguanine synthase QueE
    Primary source
    ECOCYC:G7443
    Locus tag
    b2777
    See related
    ASAP:ABE-0009101
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2771; ygcF
    Summary
    B. subtilis homolog is involved in queuosine preQ0 synthesis (Reader, 2004). [More information is available at EcoGene: EG13034].
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    Genomic context

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    Sequence:
    NC_000913.3 (2904747..2905418, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transport protein YqcE Neighboring gene putative sugar kinase YgcE Neighboring gene cell envelope stress response protein YqcG Neighboring gene TPM domain-containing protein YgcG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antimicrobial peptides trigger a division block in Escherichia coli through stimulation of a signalling system. Yadavalli SS, et al. Nat Commun, 2016 Jul 29. PMID 27471053, Free PMC Article
    2. Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism. Dowling DP, et al. Nat Chem Biol, 2014 Feb. PMID 24362703, Free PMC Article
    3. Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity. Grell TAJ, et al. Protein Sci, 2019 Jan. PMID 30341796, Free PMC Article
    4. The phosphotransferase system-dependent sucrose utilization regulon in enteropathogenic Escherichia coli strains is located in a variable chromosomal region containing iap sequences. Treviño-Quintanilla LG, et al. J Mol Microbiol Biotechnol, 2007. PMID 17693719
    5. Biosynthesis of the 7-deazaguanosine hypermodified nucleosides of transfer RNA. Iwata-Reuyl D. Bioorg Chem, 2003 Feb. PMID 12697167

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity.
      Title: Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity.
    2. QueE - a type of SAM enzyme
      Title: Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosyl-L-methionine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbon-nitrogen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in queuosine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within queuosine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative 7-carboxy-7-deazaguanine synthase QueE
    NP_417257.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2904747..2905418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417257.1 putative 7-carboxy-7-deazaguanine synthase QueE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417257.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN5FUQ9
      Conserved Domains (1) summary
      TIGR04322
      Location:9 → 223
      rSAM_QueE_Ecoli; putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE
    Nucleotide Protein
    Heading Accession and Version

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