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    tcdA tRNA threonylcarbamoyladenosine dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947291, updated on 3-Dec-2024

    Summary

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    Official Symbol
    tcdA
    Official Full Name
    tRNA threonylcarbamoyladenosine dehydratase
    Primary source
    ECOCYC:G7456
    Locus tag
    b2812
    See related
    ASAP:ABE-0009223
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    csdL; ECK2808; ygdL
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    Genomic context

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    Sequence:
    NC_000913.3 (2945036..2945842, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF903 domain-containing lipoprotein YgdI Neighboring gene cysteine sulfinate desulfinase Neighboring gene sulfur acceptor protein CsdE Neighboring gene membrane-bound lytic murein transglycosylase A Neighboring gene tRNA-Met

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The crystal structure and small-angle X-ray analysis of CsdL/TcdA reveal a new tRNA binding motif in the MoeB/E1 superfamily. López-Estepa M, et al. PLoS One, 2015. PMID 25897750, Free PMC Article
    2. The CsdA cysteine desulphurase promotes Fe/S biogenesis by recruiting Suf components and participates to a new sulphur transfer pathway by recruiting CsdL (ex-YgdL), a ubiquitin-modifying-like protein. Trotter V, et al. Mol Microbiol, 2009 Dec. PMID 20054882
    3. A cyclic form of N6-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification. Miyauchi K, et al. Nat Chem Biol, 2013 Feb. PMID 23242255
    4. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
    5. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CsdA interacts with CsdE and a newly discovered protein, called CsdL, resembling E1-like proteins found in ubiquitin-like modification systems.
      Title: The CsdA cysteine desulphurase promotes Fe/S biogenesis by recruiting Suf components and participates to a new sulphur transfer pathway by recruiting CsdL (ex-YgdL), a ubiquitin-modifying-like protein.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA threonylcarbamoyladenosine dehydratase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA threonylcarbamoyladenosine dehydratase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cyclic threonylcarbamoyladenosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cyclic threonylcarbamoyladenosine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA threonylcarbamoyladenosine dehydratase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2945036..2945842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417292.1 tRNA threonylcarbamoyladenosine dehydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417292.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M393
      Conserved Domains (1) summary
      PRK15116
      Location:1 → 268
      PRK15116; sulfur acceptor protein CsdL; Provisional
    Nucleotide Protein
    Heading Accession and Version

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