Nudt14 nudix hydrolase 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nudt14provided by MGI
Official Full Name: nudix hydrolase 14provided by MGI
Primary source: MGI:MGI:1913424
See related: Ensembl:ENSMUSG00000002804 AllianceGenome:MGI:1913424
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UGPPase; 1110030M18Rik
Summary: Enables ADP-ribose diphosphatase activity and UDP-sugar diphosphatase activity. Predicted to be involved in nucleoside phosphate metabolic process and ribose phosphate metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human NUDT14 (nudix hydrolase 14). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in colon adult (RPKM 17.1), ovary adult (RPKM 16.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 61.42 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (112897911..112905762, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (112934291..112942142, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nudt14 catalyzed the conversion of [beta-32P]UDP-glucose to [32P]glucose-1-P and UMP, confirming that it hydrolyzed the pyrophosphate of the nucleoside diphosphate sugar to generate glucose-1-P and UMP.
Title: Characterization of mouse UDP-glucose pyrophosphatase, a Nudix hydrolase encoded by the Nudt14 gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP-ribose diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-sugar diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-sugar diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nucleoside phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribose phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uridine diphosphate glucose pyrophosphatase NUDT14

Names: UDPG pyrophosphatase; nucleoside diphosphate-linked moiety X motif 14; nudix (nucleoside diphosphate linked moiety X)-type motif 14; nudix motif 14

NP_001303653.1

EC 3.6.1.45

NP_079675.1

EC 3.6.1.45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001316724.1 → NP_001303653.1 uridine diphosphate glucose pyrophosphatase NUDT14 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC160929, AK003991, CF951027, CX209884

Consensus CDS

CCDS88410.1

UniProtKB/TrEMBL

A0A217FL49

Related

ENSMUSP00000002881.5, ENSMUST00000002881.5

Conserved Domains (1) summary

TIGR00052
Location:17 → 198

TIGR00052; nudix-type nucleoside diphosphatase, YffH/AdpP family
NM_025399.4 → NP_079675.1 uridine diphosphate glucose pyrophosphatase NUDT14 isoform 1

See identical proteins and their annotated locations for NP_079675.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC160929, AK003991, BB684439, CX209884

Consensus CDS

CCDS26201.1

UniProtKB/Swiss-Prot

Q9CSD2, Q9D142

Related

ENSMUSP00000152599.2, ENSMUST00000221397.2

Conserved Domains (1) summary

TIGR00052
Location:17 → 210

TIGR00052; nudix-type nucleoside diphosphatase, YffH/AdpP family