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    Otulinl OTU deubiquitinase with linear linkage specificity like [ Mus musculus (house mouse) ]

    Gene ID: 223433, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Otulinlprovided by MGI
    Official Full Name
    OTU deubiquitinase with linear linkage specificity likeprovided by MGI
    Primary source
    MGI:MGI:2687281
    See related
    Ensembl:ENSMUSG00000056069 AllianceGenome:MGI:2687281
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam105a; 9830126M18
    Summary
    Predicted to be located in cytoplasmic side of endoplasmic reticulum membrane. Predicted to colocalize with nuclear envelope. Is expressed in embryo mesenchyme. Orthologous to human OTULINL (OTU deubiquitinase with linear linkage specificity like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 7.1), spleen adult (RPKM 5.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Otulinl in Genome Data Viewer
    Location:
    15 B1; 15 10.35 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (27655154..27681630, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (27655070..27681603, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr15:27560352-27560653 Neighboring gene OTU deubiquitinase with linear linkage specificity Neighboring gene predicted gene, 46506 Neighboring gene STARR-seq mESC enhancer starr_38229 Neighboring gene triple functional domain (PTPRF interacting) Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:27725815-27725968 Neighboring gene STARR-positive B cell enhancer ABC_E11588 Neighboring gene STARR-seq mESC enhancer starr_38230 Neighboring gene STARR-seq mESC enhancer starr_38231 Neighboring gene STARR-seq mESC enhancer starr_38233 Neighboring gene STARR-positive B cell enhancer ABC_E5471 Neighboring gene STARR-seq mESC enhancer starr_38236 Neighboring gene STARR-seq mESC enhancer starr_38238 Neighboring gene STARR-seq mESC enhancer starr_38239 Neighboring gene STARR-seq mESC enhancer starr_38240 Neighboring gene STARR-seq mESC enhancer starr_38241 Neighboring gene predicted gene, 29975 Neighboring gene predicted gene, 19883

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice. Abdallah BM, et al. J Bone Miner Res, 2011 Jul. PMID 21308776
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC59004

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    NOT enables ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables ubiquitin-like protein peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    NOT involved_in protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    colocalizes_with nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    inactive ubiquitin thioesterase OTULINL
    Names
    family with sequence similarity 105, member A
    inactive ubiquitin thioesterase FAM105A
    protein FAM105A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242423.2 → NP_001229352.1  inactive ubiquitin thioesterase OTULINL isoform 1

      See identical proteins and their annotated locations for NP_001229352.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC158955
      Consensus CDS
      CCDS88743.1
      UniProtKB/Swiss-Prot
      Q3TVP5, Q3U8Q4, Q80WP7
      Related
      ENSMUSP00000154664.2, ENSMUST00000226145.2
      Conserved Domains (1) summary
      pfam16218
      Location:86 → 352
      Peptidase_C101; Peptidase family C101

    2. NM_001242424.2 → NP_001229353.1  inactive ubiquitin thioesterase OTULINL isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform (1).
      Source sequence(s)
      AC158955
      Consensus CDS
      CCDS88744.1
      UniProtKB/TrEMBL
      A0A2I3BPS6
      Related
      ENSMUSP00000153902.2, ENSMUST00000226170.2
      Conserved Domains (1) summary
      pfam16218
      Location:86 → 296
      Peptidase_C101; Peptidase family C101

    3. NM_001416118.1 → NP_001403047.1  inactive ubiquitin thioesterase OTULINL isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158955

    4. NM_001416119.1 → NP_001403048.1  inactive ubiquitin thioesterase OTULINL isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC158955

    5. NM_198301.3 → NP_938043.1  inactive ubiquitin thioesterase OTULINL isoform 3

      See identical proteins and their annotated locations for NP_938043.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC158955
      Consensus CDS
      CCDS27403.1
      UniProtKB/Swiss-Prot
      Q3TVP5
      Related
      ENSMUSP00000098305.4, ENSMUST00000100739.5
      Conserved Domains (1) summary
      pfam16218
      Location:86 → 302
      Peptidase_C101; Peptidase family C101

    RNA

    1. NR_183254.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158955

    2. NR_183255.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158955

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      27655154..27681630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TVP5.1 GenPept UniProtKB/Swiss-Prot:Q3TVP5

    Gene LinkOut

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