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    Crybg3 beta-gamma crystallin domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 224273, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Crybg3provided by MGI
    Official Full Name
    beta-gamma crystallin domain containing 3provided by MGI
    Primary source
    MGI:MGI:2676311
    See related
    Ensembl:ENSMUSG00000022723 AllianceGenome:MGI:2676311
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm9581; 5031404N19
    Summary
    Predicted to enable protein kinase A binding activity. Predicted to be a structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Predicted to be part of protein-containing complex. Orthologous to human CRYBG3 (crystallin beta-gamma domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 6.1), bladder adult (RPKM 5.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Crybg3 in Genome Data Viewer
    Location:
    16 C1.3; 16 34.83 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (59312451..59421410, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (59492088..59601047, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700022E09 gene Neighboring gene STARR-seq mESC enhancer starr_41108 Neighboring gene STARR-seq mESC enhancer starr_41109 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho 3 Neighboring gene ORAI calcium release-activated calcium modulator 2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_41110 Neighboring gene ribosomal oxygenase 2 Neighboring gene RIKEN cDNA 4930547E14 gene Neighboring gene STARR-positive B cell enhancer ABC_E11790 Neighboring gene ADP-ribosylation factor-like 6 Neighboring gene Eph receptor A6 Neighboring gene STARR-seq mESC enhancer starr_41112 Neighboring gene STARR-seq mESC enhancer starr_41113 Neighboring gene predicted gene 4660

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Aggregation-prone near-native intermediate formation during unfolding of a structurally similar nonlenticular βγ-crystallin domain. Rajanikanth V, et al. Biochemistry, 2012 Oct 30. PMID 23043265
    2. Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene. Mori M, et al. Exp Eye Res, 2013 Jul. PMID 23631845
    3. Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene. Mori M, et al. Mamm Genome, 2022 Sep. PMID 35067752
    4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The crystal structure determined at 1.86 A demonstrates that the beta-gamma crystallin domain of Crybg3 resembles more closely the lens beta-gamma crystallins than the microbial crystallins do.
      Title: Aggregation-prone near-native intermediate formation during unfolding of a structurally similar nonlenticular βγ-crystallin domain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Spontaneous (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC58045

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in eye development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta/gamma crystallin domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174848.4 → NP_777273.3  beta/gamma crystallin domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      AC154473, AC154854
      Consensus CDS
      CCDS28258.2
      UniProtKB/TrEMBL
      A0A338P6N4
      Related
      ENSMUSP00000156047.2, ENSMUST00000172910.3
      Conserved Domains (4) summary
      COG1766
      Location:1658 → 1840
      FliF; Flagellar biosynthesis/type III secretory pathway M-ring protein FliF/YscJ [Cell motility, Intracellular trafficking, secretion, and vesicular transport]
      cd00161
      Location:2820 → 2949
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00030
      Location:2460 → 2543
      Crystall; Beta/Gamma crystallin
      cl02528
      Location:2390 → 2428
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      59312451..59421410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159903.1 → XP_036015796.1  beta/gamma crystallin domain-containing protein 3 isoform X1

      Conserved Domains (3) summary
      COG1766
      Location:1568 → 1750
      FliF; Flagellar biosynthesis/type III secretory pathway M-ring protein FliF/YscJ [Cell motility, Intracellular trafficking, secretion, and vesicular transport]
      pfam00030
      Location:2463 → 2546
      Crystall; Beta/Gamma crystallin
      pfam00652
      Location:2731 → 2857
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80W49.2 GenPept UniProtKB/Swiss-Prot:Q80W49

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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