U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pld1 phospholipase D1 [ Mus musculus (house mouse) ]

    Gene ID: 18805, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pld1provided by MGI
    Official Full Name
    phospholipase D1provided by MGI
    Primary source
    MGI:MGI:109585
    See related
    Ensembl:ENSMUSG00000027695 AllianceGenome:MGI:109585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pld1a; Pld1b; mPLD1
    Summary
    Predicted to enable phospholipase D activity. Acts upstream of or within defense response to Gram-positive bacterium. Predicted to be located in several cellular components, including Golgi cisterna; cytoplasmic vesicle; and lamellipodium. Predicted to be active in cholinergic synapse; cytoplasmic vesicle; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (phospholipase D1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in large intestine adult (RPKM 8.9), bladder adult (RPKM 4.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pld1 in Genome Data Viewer
    Location:
    3 A3; 3 11.15 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (27992636..28187388)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (27938459..28133362)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07251 Neighboring gene predicted gene, 42195 Neighboring gene predicted gene, 57707 Neighboring gene STARR-seq mESC enhancer starr_07254 Neighboring gene STARR-seq mESC enhancer starr_07256 Neighboring gene STARR-seq mESC enhancer starr_07258 Neighboring gene STARR-seq mESC enhancer starr_07259 Neighboring gene predicted gene, 42196 Neighboring gene predicted gene, 54170 Neighboring gene TRAF2 and NCK interacting kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase D activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipase D activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase D activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nutrient ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within phospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in phospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microvillus assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phospholipase D1
    Names
    choline phosphatase 1
    phosphatidylcholine-hydrolyzing phospholipase D1
    NP_001157528.1
    NP_001355596.1
    NP_001397459.1
    NP_001397460.1
    NP_001397461.1
    NP_032901.2
    XP_017174978.1
    XP_017174979.1
    XP_017174980.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164056.2NP_001157528.1  phospholipase D1 isoform 1

      See identical proteins and their annotated locations for NP_001157528.1

      Status: VALIDATED

      Source sequence(s)
      AC114987, AC132149
      Consensus CDS
      CCDS17275.1
      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      Q6NVF2
      Related
      ENSMUSP00000113810.2, ENSMUST00000120834.8
      Conserved Domains (1) summary
      PLN02866
      Location:821021
      PLN02866; phospholipase D
    2. NM_001368667.2NP_001355596.1  phospholipase D1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114987, AC132149
      Consensus CDS
      CCDS89617.1
      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      D6RH77
      Related
      ENSMUSP00000118727.3, ENSMUST00000123539.8
      Conserved Domains (1) summary
      PLN02866
      Location:821059
      PLN02866; phospholipase D
    3. NM_001410530.1NP_001397459.1  phospholipase D1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114987, AC132149
      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      D6RH77
    4. NM_001410531.1NP_001397460.1  phospholipase D1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114987, AC132149
      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      Q6NVF2
    5. NM_001410532.1NP_001397461.1  phospholipase D1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114987, AC132149
      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      Q6NVF2
    6. NM_008875.5NP_032901.2  phospholipase D1 isoform 1

      See identical proteins and their annotated locations for NP_032901.2

      Status: VALIDATED

      Source sequence(s)
      AC114987, AC132149
      Consensus CDS
      CCDS17275.1
      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      Q6NVF2
      Related
      ENSMUSP00000064694.5, ENSMUST00000067757.11
      Conserved Domains (1) summary
      PLN02866
      Location:821021
      PLN02866; phospholipase D

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      27992636..28187388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319490.3XP_017174979.1  phospholipase D1 isoform X1

      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      D6RH77
      Conserved Domains (1) summary
      PLN02866
      Location:821059
      PLN02866; phospholipase D
    2. XM_017319489.3XP_017174978.1  phospholipase D1 isoform X1

      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      D6RH77
      Conserved Domains (1) summary
      PLN02866
      Location:821059
      PLN02866; phospholipase D
    3. XM_017319491.3XP_017174980.1  phospholipase D1 isoform X1

      UniProtKB/Swiss-Prot
      O35911, Q9Z280
      UniProtKB/TrEMBL
      D6RH77
      Conserved Domains (1) summary
      PLN02866
      Location:821059
      PLN02866; phospholipase D