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    Arfgap1 ARF GTPase activating protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 228998, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Arfgap1provided by MGI
    Official Full Name
    ARF GTPase activating protein 1provided by MGI
    Primary source
    MGI:MGI:2183559
    See related
    Ensembl:ENSMUSG00000027575 AllianceGenome:MGI:2183559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arf1gap
    Summary
    Predicted to enable GTPase activator activity. Acts upstream of or within regulation of endocytosis. Located in postsynaptic density. Is expressed in axial skeleton; craniocervical region bone; inner ear; lower jaw mesenchyme; and neocortex. Orthologous to human ARFGAP1 (ARF GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 31.8), ovary adult (RPKM 22.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arfgap1 in Genome Data Viewer
    Location:
    2 H4; 2 103.53 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180608290..180624319)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180967225..180982526)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene baculoviral IAP repeat-containing 7 Neighboring gene Na+/K+ transporting ATPase interacting 4 Neighboring gene STARR-seq mESC enhancer starr_06745 Neighboring gene collagen, type XX, alpha 1 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High abundance of ArfGAP1 found in the mossy fibers in hilus of the dentate gyrus region of the mouse brain. Chornyy S, et al. PLoS One, 2017. PMID 29240824, Free PMC Article
    2. Arf1 dissociates from the clathrin adaptor GGA prior to being inactivated by Arf GTPase-activating proteins. Jacques KM, et al. J Biol Chem, 2002 Dec 6. PMID 12376537
    3. Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold. Yang Y, et al. Hum Mol Genet, 2003 May 1. PMID 12700166
    4. GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. Stafa K, et al. PLoS Genet, 2012. PMID 22363216, Free PMC Article
    5. ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2. Xiong Y, et al. J Neurosci, 2012 Mar 14. PMID 22423108, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest that ArfGAP1 can be used as a specific marker of the dentate mossy fibers and as for visualization of cortical layers in immunohistochemical studies
      Title: High abundance of ArfGAP1 found in the mossy fibers in hilus of the dentate gyrus region of the mouse brain.
    2. termination of Arf1 signals mediated through GGA require that Arf1.GTP dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP
      Title: Arf1 dissociates from the clathrin adaptor GGA prior to being inactivated by Arf GTPase-activating proteins.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of ARF protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor GTPase-activating protein 1
    Names
    ADP-ribosylation factor 1 GTPase activating protein
    ADP-ribosylation factor GTPase activating protein 1
    ARF GAP 1
    ARF1 GAP
    ARF1-directed GTPase-activating protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177706.2 → NP_001171177.1  ADP-ribosylation factor GTPase-activating protein 1 isoform b

      See identical proteins and their annotated locations for NP_001171177.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment near the C-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      BX649560
      Consensus CDS
      CCDS50843.1
      UniProtKB/TrEMBL
      Q6PB94
      Related
      ENSMUSP00000104487.2, ENSMUST00000108859.8
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    2. NM_001177707.1 → NP_001171178.1  ADP-ribosylation factor GTPase-activating protein 1 isoform c

      See identical proteins and their annotated locations for NP_001171178.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) lacks an internal segment near the C-terminus, compared to isoform a. Both variants 4 and 5 encode the same isoform.
      Source sequence(s)
      AK134402, AK145879, BY630306, CJ149044
      Consensus CDS
      CCDS50842.1
      UniProtKB/TrEMBL
      Q3TGS9, Q6PB94
      Related
      ENSMUSP00000104489.2, ENSMUST00000108861.8
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    3. NM_001177708.1 → NP_001171179.1  ADP-ribosylation factor GTPase-activating protein 1 isoform c

      See identical proteins and their annotated locations for NP_001171179.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) lacks an internal segment near the C-terminus, compared to isoform a. Both variants 4 and 5 encode the same isoform.
      Source sequence(s)
      AK145879, AK168602, BY630306, CJ149044
      Consensus CDS
      CCDS50842.1
      UniProtKB/TrEMBL
      Q3TGS9, Q6PB94
      Related
      ENSMUSP00000104490.2, ENSMUST00000108862.8
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    4. NM_001177709.1 → NP_001171180.1  ADP-ribosylation factor GTPase-activating protein 1 isoform b

      See identical proteins and their annotated locations for NP_001171180.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment near the C-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK145879, BC059817, BY630306, CJ150232
      Consensus CDS
      CCDS50843.1
      UniProtKB/TrEMBL
      Q6PB94
      Related
      ENSMUSP00000104488.2, ENSMUST00000108860.8
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    5. NM_001177710.1 → NP_001171181.1  ADP-ribosylation factor GTPase-activating protein 1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (d) lacks an internal segment near the N-terminus, compared to isoform a.
      Source sequence(s)
      BX649560
      UniProtKB/TrEMBL
      Q05DE0
      Related
      ENSMUST00000136590.8
      Conserved Domains (2) summary
      pfam13257
      Location:262 → 313
      DUF4048; Domain of unknown function (DUF4048)
      cl02464
      Location:2 → 71
      ArfGap; Putative GTPase activating protein for Arf

    6. NM_001363035.1 → NP_001349964.1  ADP-ribosylation factor GTPase-activating protein 1 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 8, encodes isoform e.
      Source sequence(s)
      BX649560
      Consensus CDS
      CCDS89604.1
      UniProtKB/TrEMBL
      Q6PB94, V9GWV1
      Related
      ENSMUSP00000138843.2, ENSMUST00000184394.2
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    7. NM_001363036.1 → NP_001349965.1  ADP-ribosylation factor GTPase-activating protein 1 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 7, encodes isoform e.
      Source sequence(s)
      BX649560
      Consensus CDS
      CCDS89604.1
      UniProtKB/TrEMBL
      Q6PB94, V9GWV1
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    8. NM_001363037.1 → NP_001349966.1  ADP-ribosylation factor GTPase-activating protein 1 isoform f

      Status: VALIDATED

      Source sequence(s)
      BX649560
      UniProtKB/TrEMBL
      Q6PB94
      Conserved Domains (1) summary
      cl27571
      Location:2 → 71
      ArfGap; Putative GTPase activating protein for Arf

    9. NM_001374670.1 → NP_001361599.1  ADP-ribosylation factor GTPase-activating protein 1 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) encodes the longest isoform (g).
      Source sequence(s)
      BX649560
      Consensus CDS
      CCDS89603.1
      UniProtKB/TrEMBL
      Q6PB94, V9GXM1
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    10. NM_145760.3 → NP_665703.2  ADP-ribosylation factor GTPase-activating protein 1 isoform a

      See identical proteins and their annotated locations for NP_665703.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AK145879, BY630306, CJ149044
      Consensus CDS
      CCDS17190.1
      UniProtKB/Swiss-Prot
      A8WIR9, A8WIS1, Q3TI52, Q8BMM6, Q8BMQ7, Q9EPJ9
      UniProtKB/TrEMBL
      Q6PB94
      Related
      ENSMUSP00000029092.7, ENSMUST00000029092.13
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      180608290..180624319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161736.1 → XP_036017629.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A8WIR9, A8WIS1, Q3TI52, Q8BMM6, Q8BMQ7, Q9EPJ9
      UniProtKB/TrEMBL
      Q6PB94
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    2. XM_030250858.2 → XP_030106718.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X5

      UniProtKB/TrEMBL
      Q6PB94
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    3. XM_030250845.2 → XP_030106705.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A8WIR9, A8WIS1, Q3TI52, Q8BMM6, Q8BMQ7, Q9EPJ9
      UniProtKB/TrEMBL
      Q6PB94
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    4. XM_006500594.3 → XP_006500657.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006500657.1

      UniProtKB/TrEMBL
      Q6PB94, V9GXM1
      Related
      ENSMUSP00000139222.2, ENSMUST00000185115.8
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    5. XM_030250844.2 → XP_030106704.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A8WIR9, A8WIS1, Q3TI52, Q8BMM6, Q8BMQ7, Q9EPJ9
      UniProtKB/TrEMBL
      Q6PB94
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    6. XM_030250846.1 → XP_030106706.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X3

      UniProtKB/TrEMBL
      Q6PB94, V9GWV1
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    7. XM_030250848.1 → XP_030106708.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X4

      UniProtKB/TrEMBL
      Q3TGS9, Q6PB94
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    8. XM_030250850.2 → XP_030106710.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X5

      UniProtKB/TrEMBL
      Q6PB94
      Conserved Domains (1) summary
      cd08830
      Location:6 → 121
      ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

    9. XM_011239936.3 → XP_011238238.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X6

    RNA

    1. XR_001782401.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPJ9.2 GenPept UniProtKB/Swiss-Prot:Q9EPJ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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