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    Fbxl7 F-box and leucine-rich repeat protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 448987, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbxl7provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 7provided by MGI
    Primary source
    MGI:MGI:3052506
    See related
    Ensembl:ENSMUSG00000043556 AllianceGenome:MGI:3052506
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBL7; Fbl6; D230018M15Rik
    Summary
    Involved in G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Located in centrosome. Part of SCF ubiquitin ligase complex. Orthologous to human FBXL7 (F-box and leucine rich repeat protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 5.8), ovary adult (RPKM 5.0) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fbxl7 in Genome Data Viewer
    Location:
    15 B1; 15 9.87 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (26540540..26895650, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (26540454..26895564, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene membrane associated ring-CH-type finger 11 Neighboring gene STARR-seq mESC enhancer starr_38209 Neighboring gene STARR-seq mESC enhancer starr_38210 Neighboring gene predicted gene, 36790 Neighboring gene predicted gene, 52206 Neighboring gene STARR-seq mESC enhancer starr_38211 Neighboring gene predicted gene, 52205 Neighboring gene gem-associated protein 4-like Neighboring gene ecdysoneless homolog pseudogene Neighboring gene predicted gene, 18093 Neighboring gene STARR-seq mESC enhancer starr_38213 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 23903

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102204

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176959.3NP_795933.2  F-box/LRR-repeat protein 7

      See identical proteins and their annotated locations for NP_795933.2

      Status: PROVISIONAL

      Source sequence(s)
      BC091646
      Consensus CDS
      CCDS37052.1
      UniProtKB/Swiss-Prot
      Q5BJ29, Q6ZQ36
      Related
      ENSMUSP00000061305.10, ENSMUST00000059204.11
      Conserved Domains (3) summary
      cd09293
      Location:297464
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:240273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:114160
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      26540540..26895650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520106.5XP_006520169.1  F-box/LRR-repeat protein 7 isoform X1

      See identical proteins and their annotated locations for XP_006520169.1

      Conserved Domains (3) summary
      cd09293
      Location:250417
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:193226
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:67110
      F-box-like