Styxl2 serine/threonine/tyrosine interacting like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Styxl2provided by MGI
Official Full Name: serine/threonine/tyrosine interacting like 2provided by MGI
Primary source: MGI:MGI:2685055
See related: Ensembl:ENSMUSG00000026564 AllianceGenome:MGI:2685055
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm209; Dusp27; C130085G02Rik
Summary: Predicted to enable MAP kinase phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade. Predicted to be located in sarcomere. Predicted to be active in cytoplasm. Is expressed in heart; limb muscle; lung; skeletal muscle; and somite. Orthologous to human STYXL2 (serine/threonine/tyrosine interacting like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in heart adult (RPKM 1.8), limb E14.5 (RPKM 0.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.3; 1 73.45 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (165925717..165955467, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (166098148..166127898, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation.
Title: Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine/serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcomere	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine/tyrosine-interacting-like protein 2

Names: dual specificity phosphatase 27 (putative); inactive dual specificity phosphatase 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033344.3 → NP_001028516.2 serine/threonine/tyrosine-interacting-like protein 2

See identical proteins and their annotated locations for NP_001028516.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AK142263, BC059034, BY730343

Consensus CDS

CCDS15446.1

UniProtKB/Swiss-Prot

Q148W8, Q3UQN8, Q6PCZ9, Q8BX87

Related

ENSMUSP00000083155.3, ENSMUST00000085992.4

Conserved Domains (1) summary

cd00127
Location:133 → 275

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
NM_001160049.1 → NP_001153521.1 serine/threonine/tyrosine-interacting-like protein 2

See identical proteins and their annotated locations for NP_001153521.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AK048603, AK142263, BC059034

Consensus CDS

CCDS15446.1

UniProtKB/Swiss-Prot

Q148W8, Q3UQN8, Q6PCZ9, Q8BX87

Related

ENSMUSP00000141564.2, ENSMUST00000192369.6

Conserved Domains (1) summary

cd00127
Location:133 → 275

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...