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    Pcnt pericentrin (kendrin) [ Mus musculus (house mouse) ]

    Gene ID: 18541, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pcntprovided by MGI
    Official Full Name
    pericentrin (kendrin)provided by MGI
    Primary source
    MGI:MGI:102722
    See related
    Ensembl:ENSMUSG00000001151 AllianceGenome:MGI:102722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KEN; Pcnt2; kendrin; m239Asp; m275Asp
    Summary
    Predicted to enable calmodulin binding activity and molecular adaptor activity. Acts upstream of or within several processes, including embryonic organ development; mitotic spindle organization; and nervous system development. Located in several cellular components, including cis-Golgi network; intercellular bridge; and microtubule organizing center. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; respiratory system; and sensory organ. Used to study microcephalic osteodysplastic primordial dwarfism type II. Human ortholog(s) of this gene implicated in microcephalic osteodysplastic primordial dwarfism type II. Orthologous to human PCNT (pericentrin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 7.7), lung adult (RPKM 6.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pcnt in Genome Data Viewer
    Location:
    10 C1; 10 38.8 cM
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76187098..76279988, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76351254..76442912, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene S100 protein, beta polypeptide, neural Neighboring gene disco interacting protein 2 homolog A Neighboring gene predicted gene, 40699 Neighboring gene STARR-seq mESC enhancer starr_27177 Neighboring gene RIKEN cDNA 1700094J05 gene Neighboring gene STARR-seq mESC enhancer starr_27178 Neighboring gene STARR-seq mESC enhancer starr_27179 Neighboring gene RIKEN cDNA 2610028H24 gene Neighboring gene STARR-seq mESC enhancer starr_27180 Neighboring gene STARR-seq mESC enhancer starr_27181 Neighboring gene predicted gene 9744 Neighboring gene STARR-seq mESC enhancer starr_27182 Neighboring gene ybeY metallopeptidase Neighboring gene minichromosome maintenance complex component 3 associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of pericentrin isoforms in vivo. Miyoshi K, et al. Biochem Biophys Res Commun, 2006 Dec 22. PMID 17084386
    2. Pericentrin, a centrosomal protein related to microcephalic primordial dwarfism, is required for olfactory cilia assembly in mice. Miyoshi K, et al. FASEB J, 2009 Oct. PMID 19470799
    3. Subdiffraction imaging of centrosomes reveals higher-order organizational features of pericentriolar material. Lawo S, et al. Nat Cell Biol, 2012 Nov. PMID 23086237
    4. Depletion of pericentrin in mouse oocytes disrupts microtubule organizing center function and meiotic spindle organization. Ma W, et al. Mol Reprod Dev, 2014 Nov. PMID 25266793, Free PMC Article
    5. Error-prone meiotic division and subfertility in mice with oocyte-conditional knockdown of pericentrin. Baumann C, et al. J Cell Sci, 2017 Apr 1. PMID 28193732, Free PMC Article

    See all (154) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation.
      Title: Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation.
    2. CRISPR/Cas9-mediated knockout of Syne-2 in cell culture led to an overexpression and mislocalization of Pcnt and to ciliogenesis defects. This suggests that the Pcnt-Syne-2 complex is important for ciliogenesis and outer segment formation during retinal development and plays a role in nuclear migration.
      Title: Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis.
    3. experiments demonstrate a role for Pericentrin in modulating Piezo2 activity and membrane expression in somatosensory neurons
      Title: Native Piezo2 Interactomics Identifies Pericentrin as a Novel Regulator of Piezo2 in Somatosensory Neurons.
    4. Meiotic division is highly error-prone in the absence of Pcnt and disrupted acentriolar microtubule-organizing centers.
      Title: Error-prone meiotic division and subfertility in mice with oocyte-conditional knockdown of pericentrin.
    5. Pericentrin is a key functional component of the unique acentriolar MTOCs of mouse oocytes, and plays an important role in regulating meiotic spindle assembly and/or stability.
      Title: Depletion of pericentrin in mouse oocytes disrupts microtubule organizing center function and meiotic spindle organization.
    6. The mouse Pcnt(-/-) phenotype was associated with misdirected ventricular septal growth in the heart, decreased proliferative symmetric divisions in brain neural progenitors, and increased misoriented divisions in fibroblasts.
      Title: A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation.
    7. Findings suggest distinct functional roles of several Pcnt variants in different ciliated tissues and sensory neurons, like the olfactory epithelium and the retina of the mouse
      Title: The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors.
    8. A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice
      Title: A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice.
    9. pericentrin is essential for the assembly of chemosensory cilia of olfactory receptor neurons, but it is not globally required for cilia formation in mammals.
      Title: Pericentrin, a centrosomal protein related to microcephalic primordial dwarfism, is required for olfactory cilia assembly in mice.
    10. pPKCdelta(Thr505) interacts with MTOC-associated proteins pericentrin and gamma-tubulin, and plays a role in meiotic spindle organization in oocytes
      Title: Protein kinase C delta (PKCdelta) interacts with microtubule organizing center (MTOC)-associated proteins and participates in meiotic spindle organization.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (6) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cerebellar cortex morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within head development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within olfactory bulb development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spindle organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium TAS
    Traceable Author Statement
    more info
    		  
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pericentrin
    Names
    pericentrin 2
    pericentrin-250
    pericentrin-360

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282992.2 → NP_001269921.1  pericentrin isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AC141477, AC158618
      Consensus CDS
      CCDS88027.1
      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      UniProtKB/TrEMBL
      A0A1W2P737
      Related
      ENSMUSP00000151534.2, ENSMUST00000217838.2
      Conserved Domains (6) summary
      COG1196
      Location:475 → 1375
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5281
      Location:305 → 577
      COG5281; Phage-related minor tail protein [Mobilome: prophages, transposons]
      pfam09455
      Location:1050 → 1214
      Cas_DxTHG; CRISPR-associated (Cas) DxTHG family
      pfam10495
      Location:2701 → 2779
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
      pfam12474
      Location:154 → 308
      PKK; Polo kinase kinase
      pfam15290
      Location:1413 → 1479
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    2. NM_001428741.1 → NP_001415670.1  pericentrin isoform c

      Status: VALIDATED

      Source sequence(s)
      AC141477, AC158618

    3. NM_001428742.1 → NP_001415671.1  pericentrin isoform d

      Status: VALIDATED

      Source sequence(s)
      AC141477

    4. NM_008787.4 → NP_032813.3  pericentrin isoform a

      See identical proteins and their annotated locations for NP_032813.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC141477, AC158618
      Consensus CDS
      CCDS23944.1
      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      UniProtKB/TrEMBL
      F8VPV0
      Related
      ENSMUSP00000001179.6, ENSMUST00000001179.7
      Conserved Domains (6) summary
      COG1196
      Location:475 → 1375
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5281
      Location:305 → 577
      COG5281; Phage-related minor tail protein [Mobilome: prophages, transposons]
      pfam09455
      Location:1050 → 1214
      Cas_DxTHG; CRISPR-associated (Cas) DxTHG family
      pfam10495
      Location:2719 → 2797
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
      pfam12474
      Location:154 → 308
      PKK; Polo kinase kinase
      pfam15290
      Location:1413 → 1479
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      76187098..76279988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244950.2 → XP_030100810.1  pericentrin isoform X8

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (4) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1368
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1218 → 1551
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:2789 → 2867
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    2. XM_011243383.4 → XP_011241685.1  pericentrin isoform X5

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (4) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1375
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1218 → 1558
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:2796 → 2874
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    3. XM_036155685.1 → XP_036011578.1  pericentrin isoform X13

      Conserved Domains (3) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1386
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10495
      Location:2712 → 2790
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    4. XM_017313839.3 → XP_017169328.1  pericentrin isoform X2

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (4) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1386
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1229 → 1564
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:2807 → 2885
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    5. XM_011243384.4 → XP_011241686.1  pericentrin isoform X7

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (4) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1369
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1219 → 1552
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:2790 → 2868
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    6. XM_006513353.5 → XP_006513416.1  pericentrin isoform X15

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (4) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1376
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1219 → 1559
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:2702 → 2780
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    7. XM_006513348.5 → XP_006513411.1  pericentrin isoform X10

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (4) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1376
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1219 → 1559
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:2779 → 2857
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    8. XM_011243382.4 → XP_011241684.1  pericentrin isoform X4

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (4) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1376
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1219 → 1559
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:2797 → 2875
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    9. XM_036155686.1 → XP_036011579.1  pericentrin isoform X14

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (3) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10495
      Location:2706 → 2784
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    10. XM_036155684.1 → XP_036011577.1  pericentrin isoform X9

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (3) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10495
      Location:2783 → 2861
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    11. XM_017313840.3 → XP_017169329.1  pericentrin isoform X3

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (4) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1230 → 1558
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:2801 → 2879
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    12. XM_017313843.3 → XP_017169332.1  pericentrin isoform X12

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (4) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1387
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1230 → 1565
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:2713 → 2791
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    13. XM_017313841.3 → XP_017169330.1  pericentrin isoform X6

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (4) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1387
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1230 → 1565
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:2790 → 2868
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    14. XM_017313842.3 → XP_017169331.1  pericentrin isoform X11

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (4) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1387
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1230 → 1565
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:2731 → 2809
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    15. XM_017313838.3 → XP_017169327.1  pericentrin isoform X1

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (4) summary
      PTZ00121
      Location:133 → 647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:475 → 1387
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1230 → 1565
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:2808 → 2886
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    16. XM_036155687.1 → XP_036011580.1  pericentrin isoform X16

      UniProtKB/Swiss-Prot
      A0JBT0, A0JBT1, P48725
      Conserved Domains (3) summary
      COG1196
      Location:545 → 897
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:4 → 896
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:2318 → 2396
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    17. XM_017313845.3 → XP_017169334.1  pericentrin isoform X17

      UniProtKB/TrEMBL
      Q80U10
      Conserved Domains (3) summary
      COG1196
      Location:138 → 470
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:313 → 648
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:1891 → 1969
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    18. XM_006513356.3 → XP_006513419.1  pericentrin isoform X19

      Related
      ENSMUST00000220395.2
      Conserved Domains (3) summary
      COG1196
      Location:138 → 459
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:302 → 642
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:1785 → 1863
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

    19. XM_036155688.1 → XP_036011581.1  pericentrin isoform X18

      UniProtKB/TrEMBL
      Q80U10
      Conserved Domains (3) summary
      COG1196
      Location:138 → 470
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:1114 → 1392
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam10495
      Location:1796 → 1874
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48725.2 GenPept UniProtKB/Swiss-Prot:P48725

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