Larp1 La ribonucleoprotein 1, translational regulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Larp1provided by MGI
Official Full Name: La ribonucleoprotein 1, translational regulatorprovided by MGI
Primary source: MGI:MGI:1890165
See related: Ensembl:ENSMUSG00000037331 AllianceGenome:MGI:1890165
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Larp; mKIAA0731; 1810024J12Rik; 3110040D16Rik
Summary: Predicted to enable eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and ribosomal small subunit binding activity. Predicted to be involved in several processes, including TORC1 signaling; cellular response to rapamycin; and post-transcriptional regulation of gene expression. Predicted to be located in cytoplasm. Predicted to be part of TORC1 complex. Predicted to be active in cytoplasmic stress granule and cytosol. Is expressed in several structures, including branchial arch; cranial ganglion; epithelium; future spinal cord; and limb bud. Orthologous to human LARP1 (La ribonucleoprotein 1, translational regulator). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Ubiquitous expression in testis adult (RPKM 51.6), genital fat pad adult (RPKM 17.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 35.55 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (57899711..57952860)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (57973418..58062034)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1).
Title: The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1).
Lysophosphatidic acid stimulates pericyte migration via LPA receptor 1.
Title: Lysophosphatidic acid stimulates pericyte migration via LPA receptor 1.
The RNA-binding protein LARP1 is dispensable for pancreatic beta-cell function and mass.
Title: The RNA-binding protein LARP1 is dispensable for pancreatic β-cell function and mass.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236586

AI136666 (e-PCR)
- UniSTS:261176

C88147 (e-PCR)
- UniSTS:165868

RH135912 (e-PCR)
- UniSTS:209910

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	ISO Inferred from Sequence Orthology more info
enables RNA 7-methylguanosine cap binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA cap binding	ISO Inferred from Sequence Orthology more info
enables RNA cap binding	ISS Inferred from Sequence or Structural Similarity more info
enables eukaryotic initiation factor 4E binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic initiation factor 4E binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 5'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 5'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal small subunit binding	ISO Inferred from Sequence Orthology more info
enables ribosomal small subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation activator activity	ISO Inferred from Sequence Orthology more info
enables translation activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to rapamycin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to rapamycin	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of macroautophagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translational initiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of TORC1 complex	ISO Inferred from Sequence Orthology more info
part_of TORC1 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISA Inferred from Sequence Alignment more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: la-related protein 1

Names: La ribonucleoprotein domain family, member 1; la related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028451.1 → NP_082727.1 la-related protein 1

Status: VALIDATED

Source sequence(s)

AL672182

Consensus CDS

CCDS56771.1

UniProtKB/Swiss-Prot

A2AFQ8, J3QNB1, Q6ZQ58, Q7TSF7

UniProtKB/TrEMBL

Z4YJT3

Related

ENSMUSP00000136673.2, ENSMUST00000178636.2

Conserved Domains (2) summary

smart00684
Location:903 → 941

DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function

cd08034
Location:379 → 451

LARP_1_2; La RNA-binding domain proteins similar to La-related proteins 1 and 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

57899711..57952860

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157022.1 → XP_036012915.1 la-related protein 1 isoform X2

UniProtKB/TrEMBL

Z4YJT3

Conserved Domains (4) summary

smart00684
Location:725 → 763

DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function

PTZ00449
Location:2 → 111

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

COG5193
Location:171 → 355

LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]

cl02755
Location:201 → 273

LAM; LA motif RNA-binding domain
XM_006534334.4 → XP_006534397.2 la-related protein 1 isoform X1

UniProtKB/TrEMBL

Z4YJT3

Conserved Domains (4) summary

smart00684
Location:795 → 833

DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function

PTZ00449
Location:62 → 181

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

COG5193
Location:241 → 425

LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]

cl02755
Location:271 → 343

LAM; LA motif RNA-binding domain