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    Mapk13 mitogen activated protein kinase 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29513, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mapk13provided by RGD
    Official Full Name
    mitogen activated protein kinase 13provided by RGD
    Primary source
    RGD:3045
    See related
    EnsemblRapid:ENSRNOG00000000515 AllianceGenome:RGD:3045
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prkm13
    Summary
    Enables ATP binding activity and MAP kinase activity. Involved in protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPK13 (mitogen-activated protein kinase 13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 272.5), Lung (RPKM 47.0) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mapk13 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (6836979..6847197)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (6835277..6845500)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (6018374..6027467)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene mitogen activated protein kinase 14 Neighboring gene uncharacterized LOC134483779 Neighboring gene bromodomain and PHD finger containing, 3 Neighboring gene uncharacterized LOC134483867 Neighboring gene uncharacterized LOC120098863 Neighboring gene patatin-like phospholipase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. p38 MAPK regulates G1-S transition in hypoxic cardiac fibroblasts. Pillai MS, et al. Int J Biochem Cell Biol, 2011 Jun. PMID 21420505
    2. Rat mesothelioma cell proliferation requires p38δ mitogen activated protein kinase and C/EBP-α. Zhong J, et al. Lung Cancer, 2011 Aug. PMID 21227534
    3. Identification of stathmin as a novel substrate for p38 delta. Parker CG, et al. Biochem Biophys Res Commun, 1998 Aug 28. PMID 9731215
    4. Microtubular stability affects pVHL-mediated regulation of HIF-1alpha via the p38/MAPK pathway in hypoxic cardiomyocytes. Teng M, et al. PLoS One, 2012. PMID 22506063, Free PMC Article
    5. Physiological loading of joints prevents cartilage degradation through CITED2. Leong DJ, et al. FASEB J, 2011 Jan. PMID 20826544, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
      Title: The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
    2. Microtubular structure breakdown activated p38/MAPK pathway, accompanied with the upregulation of pVHL.
      Title: Microtubular stability affects pVHL-mediated regulation of HIF-1alpha via the p38/MAPK pathway in hypoxic cardiomyocytes.
    3. in pleural mesothelioma, p38 delta and C/EBP-alpha mediate proliferation and thus may represent new targets in mesothelioma therapy
      Title: Rat mesothelioma cell proliferation requires p38δ mitogen activated protein kinase and C/EBP-α.
    4. regulates G1-S transition in hypoxic cardiac fibroblasts
      Title: p38 MAPK regulates G1-S transition in hypoxic cardiac fibroblasts.
    5. Studies identify a novel regulatory pathway involving CITED2 and p38delta, which may be critical for the maintenance of articular cartilage integrity under normal physical activity levels.
      Title: Physiological loading of joints prevents cartilage degradation through CITED2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC124619

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to UV IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to anisomycin IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to anisomycin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to sodium arsenite IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to sodium arsenite ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to sorbitol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to sorbitol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to osmotic stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress-activated MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress-activated MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 13
    Names
    MAP kinase 13
    MAP kinase p38 delta
    MAPK 13
    mitogen-activated protein kinase p38 delta
    stress-activated protein kinase 4
    NP_062104.3
    XP_038954553.1
    XP_063135153.1
    XP_063135154.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019231.3 → NP_062104.3  mitogen-activated protein kinase 13

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6JJS2, G3V618, Q32Q45
      Related
      ENSRNOP00000000621.4, ENSRNOT00000000621.8
      Conserved Domains (1) summary
      cd07879
      Location:9 → 351
      STKc_p38delta; Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      6836979..6847197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279083.1 → XP_063135153.1  mitogen-activated protein kinase 13 isoform X1

    2. XM_063279084.1 → XP_063135154.1  mitogen-activated protein kinase 13 isoform X3

    3. XM_039098625.2 → XP_038954553.1  mitogen-activated protein kinase 13 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1 → 273
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTY9.1 GenPept UniProtKB/Swiss-Prot:Q9WTY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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