Sfrp4 secreted frizzled-related protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sfrp4provided by RGD
Official Full Name: secreted frizzled-related protein 4provided by RGD
Primary source: RGD:621075
See related: EnsemblRapid:ENSRNOG00000054957 AllianceGenome:RGD:621075
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables Wnt-protein binding activity. Involved in several processes, including decidualization; mammary gland involution; and negative regulation of signal transduction. Located in extracellular space. Human ortholog(s) of this gene implicated in metaphyseal dysplasia. Orthologous to human SFRP4 (secreted frizzled related protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 198.2), Muscle (RPKM 100.3) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (49974532..50026448, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (45278867..45330806, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (47383983..47394065, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MeCP2 attenuates cardiomyocyte hypoxia/reperfusion-induced injury via regulation of the SFRP4/Wnt/beta-catenin axis.
Title: MeCP2 attenuates cardiomyocyte hypoxia/reperfusion-induced injury via regulation of the SFRP4/Wnt/β-catenin axis.
Increased SFRP4 down-regulated the key gene beta-catenin, the downstream effectors gene ccnd1 and fibronectin expression in canonical Wnt pathway at the same time.
Title: MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast-like synoviocytes in rats.
Hydroxytyrosol alters several genes associated with cell proliferation, apoptosis and the Wnt signalling pathway, promoting a high expression of Sfrp4 in rat mammary tumors.
Title: Hydroxytyrosol inhibits growth and cell proliferation and promotes high expression of sfrp4 in rat mammary tumours.
Differential expression of secreted frizzled-related protein 4 in decidual cells during pregnancy.
Title: Differential expression of secreted frizzled-related protein 4 in decidual cells during pregnancy.
Regulation of sFRP-4 by LH and PRL may be important for modulating Fz-1, known to be expressed in periovulatory follicles, and Wnt-4/Fz-4, which are expressed in corpora lutea.
Title: Expression and localization of secreted frizzled-related protein-4 in the rodent ovary: evidence for selective up-regulation in luteinized granulosa cells.
observations support the hypothesis that increased placental expression of SFRP4 inhibits the WNT pathway and thereby influences placental growth via effects on cell fate signaling
Title: Placental expression of secreted frizzled related protein-4 in the rat and the impact of glucocorticoid-induced fetal and placental growth restriction.
This study demonstrates an association between Secreted Frizzled Related Protein 4 and apoptosis during rat ovulation.
Title: The role of sFRP4, a secreted frizzled-related protein, in ovulation.

Submit: New GeneRIF Correction

General gene information

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Markers

Sfrp4 (e-PCR), detects polymorphism
- UniSTS:527126

Sfrp4 (e-PCR), detects polymorphism
- UniSTS:471845

D17Wox29 (e-PCR)
- UniSTS:518501

RH137177 (e-PCR)
- UniSTS:219265

RH141728 (e-PCR)
- UniSTS:223721

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in bone morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in bone morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in bone morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in decidualization	IEP Inferred from Expression Pattern more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in mammary gland involution	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of sodium-dependent phosphate transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of sodium-dependent phosphate transport	ISO Inferred from Sequence Orthology more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: secreted frizzled-related protein 4

Names: DDC-4 protein; FRP; frizzled related protein; sFRP-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053544.2 → NP_445996.2 secreted frizzled-related protein 4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A6KN49, G3V8G7

Related

ENSRNOP00000075046.2, ENSRNOT00000079368.3

Conserved Domains (3) summary

COG3087
Location:267 → 345

FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]

cl02447
Location:20 → 146

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

cl02512
Location:188 → 296

NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

49974532..50026448 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096132.2 → XP_038952060.1 secreted frizzled-related protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZZG6

Conserved Domains (2) summary

cl02447
Location:20 → 146

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

cl02512
Location:188 → 284

NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
XM_039096133.2 → XP_038952061.1 secreted frizzled-related protein 4 isoform X3

Conserved Domains (2) summary

COG3087
Location:147 → 225

FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]

cl02512
Location:68 → 176

NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
XM_063276786.1 → XP_063132856.1 secreted frizzled-related protein 4 isoform X2

UniProtKB/TrEMBL

A0A8I6GL00, Q924N2