Fadd Fas associated via death domain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Faddprovided by RGD
Official Full Name: Fas associated via death domainprovided by RGD
Primary source: RGD:628700
See related: EnsemblRapid:ENSRNOG00000047035 AllianceGenome:RGD:628700
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mort1
Summary: Enables protease binding activity; receptor serine/threonine kinase binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in behavioral response to cocaine; kidney development; and regulation of necroptotic process. Located in cell body. Part of CD95 death-inducing signaling complex. Used to study morphine dependence and prostatic hypertrophy. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; brain glioma; cerebrovascular disease (multiple); depressive disorder; and obesity. Human ortholog(s) of this gene implicated in leukemia and primary immunodeficiency disease. Orthologous to human FADD (Fas associated via death domain). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 55.5), Kidney (RPKM 54.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q42

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (209169245..209175423, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (199743200..199745746, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (217746176..217748581, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that hypothermic effects induced by acute 8-OH-DPAT are associated with better cognitive scores and lower FADD content in the hippocampus of rats at different ages. In addition acute, but not repeated, 8-OH-DPAT treatments further decrease hippocampal FADD protein in rats at different ages.
Title: Improved age-related deficits in cognitive performance and affective-like behavior following acute, but not repeated, 8-OH-DPAT treatments in rats: regulation of hippocampal FADD.
Western blotting demonstrated that expression of CD95, FasL and FADD was very weak during embryonic development, but rapidly increased at P14.
Title: Differential activation of CD95-mediated apoptosis related proteins in proximal and distal tubules during rat renal development.
Results reveal a novel myocardial necrosis regulation model, which is composed of H19, miR-103/107, and FADD.
Title: MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADD.
Results show that both infliximab and methylprednisolone (MP) could lower the expressions of NF-kappaB, TRADD, and FADD 24 hours after the acute spinal cord injury (ASCI).
Title: Effect of infliximab combined with methylprednisolone on expressions of NF-κB, TRADD, and FADD in rat acute spinal cord injury.
cortical oligomeric p-FADD, mainly through an interaction with inhibitory alpha(2)-adrenoceptors, plays a functional role in the behavioural expression of morphine abstinence in rats.
Title: Correlation of rat cortical Fas-associated death domain (FADD) protein phosphorylation with the severity of spontaneous morphine abstinence syndrome: role of α(2)-adrenoceptors and extracellular signal-regulated kinases.
Fas-Associated protein with Death Domain (FADD), a molecular marker previously associated with the propensity to substance abuse and cocaine sensitization, was found to be a cell fate regulator during cocaine withdrawal.
Title: Decreased proliferation of adult hippocampal stem cells during cocaine withdrawal: possible role of the cell fate regulator FADD.
findings show FADD is a signaling protein modulated by cocaine, regulating apoptosis/proliferative mechanisms in relation to its FADD/pFADD content
Title: Effect of cocaine on Fas-associated protein with death domain in the rat brain: individual differences in a model of differential vulnerability to drug abuse.
In EC-SMC coculture, pressure upregulates SMC apoptosis SMCs through EC-derived paracrine factors and that SMC apoptosis is induced through Fas-Fas ligand (FasL) activation.
Title: Pressure and endothelial coculture upregulate myocytic Fas-FasL pathway and induce apoptosis by way of direct and paracrine mechanisms.
These data indicate that FADD protein expression can increase rapidly in hepatocytes exposed to broadly cytotoxic agents.
Title: Hepatocyte Fas-associating death domain protein/mediator of receptor-induced toxicity (FADD/MORT1) levels increase in response to pro-apoptotic stimuli.
Data indicate that cAMP and cGMP prevent TNFalpha/ActD-induced apoptosis in hepatocytes and that this occurs in association with a near complete inhibition of the upregulation of FADD via a PKA-dependent mechanism.
Title: Cyclic AMP and cyclic GMP suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation via a protein kinase A-dependent pathway.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127743 (e-PCR)
- UniSTS:211053

PMC305633P1 (e-PCR)
- UniSTS:272553

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables caspase binding	IBA Inferred from Biological aspect of Ancestor more info
enables caspase binding	ISO Inferred from Sequence Orthology more info
enables death effector domain binding	ISO Inferred from Sequence Orthology more info
enables death receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables death receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables receptor serine/threonine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor superfamily binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation in thymus	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in T cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in TRAIL-activated apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in death-inducing signaling complex assembly	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lymph node development	ISO Inferred from Sequence Orthology more info
involved_in lymph node development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within motor neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activation-induced cell death of T cells	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activation-induced cell death of T cells	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adaptive immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in spleen development	ISO Inferred from Sequence Orthology more info
involved_in spleen development	ISS Inferred from Sequence or Structural Similarity more info
involved_in thymus development	ISO Inferred from Sequence Orthology more info
involved_in thymus development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of CD95 death-inducing signaling complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CD95 death-inducing signaling complex	IDA Inferred from Direct Assay more info	PubMed
part_of CD95 death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of death-inducing signaling complex	IDA Inferred from Direct Assay more info	PubMed
part_of death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of ripoptosome	ISO Inferred from Sequence Orthology more info
part_of ripoptosome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: FAS-associated death domain protein

Names: Fas (TNFRSF6)-associated via death domain; protein FADD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152937.2 → NP_690920.1 FAS-associated death domain protein

See identical proteins and their annotated locations for NP_690920.1

Status: PROVISIONAL

Source sequence(s)

AF406779

UniProtKB/TrEMBL

M0R9V8, Q8R2E7

Related

ENSRNOP00000066289.1, ENSRNOT00000075089.5

Conserved Domains (2) summary

cd08306
Location:97 → 181

Death_FADD; Fas-associated Death Domain protein-protein interaction domain

cd08336
Location:19 → 83

DED_FADD; Death Effector Domain found in Fas-Associated via Death Domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

209169245..209175423 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102426.2 → XP_038958354.1 FAS-associated death domain protein isoform X1

Conserved Domains (1) summary

cd08336
Location:19 → 83

DED_FADD; Death Effector Domain found in Fas-Associated via Death Domain