Slco1b2 solute carrier organic anion transporter family member 1B2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slco1b2provided by RGD
Official Full Name: solute carrier organic anion transporter family member 1B2provided by RGD
Primary source: RGD:69300
See related: EnsemblRapid:ENSRNOG00000030538 AllianceGenome:RGD:69300
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oatp4; OATP-4; rlst-1; Slco1b3; Slc21a10
Summary: Enables bile acid transmembrane transporter activity and oligopeptide transmembrane transporter activity. Involved in several processes, including bile acid and bile salt transport; response to glucocorticoid; and response to lipopolysaccharide. Located in basolateral plasma membrane. Used to study bilirubin metabolic disorder. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder and gastrointestinal stromal tumor. Orthologous to several human genes including SLCO1B3 (solute carrier organic anion transporter family member 1B3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 2829.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q44

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (176282577..176355557)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (174551463..174619988)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (175814118..175881775)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

investigation of role of OATP1B3 in drug metabolism/distribution: Data indicate that hepatic uptake of telmisartan mainly consists of a saturable process mediated by OATP1B3.
Title: The involvement of organic anion transporting polypeptide in the hepatic uptake of telmisartan in rats: PET studies with [¹¹C]telmisartan.
Oatp2 and Oatp4 levels were unaffected during obstructive cholestasis.
Title: Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver.
Detailed DNA sequence analysis reveales major functional features of the sequence.
Title: Determination of transcription start site and analysis of promoter sequence, splice junction sites, intron sequence and codon usage bias of rat liver-specific organic anion transporter-1 (rlst-1/Oatp-4/Slc21a10) gene.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables oligopeptide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid and bile salt transport	IDA Inferred from Direct Assay more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in oligopeptide transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in oligopeptide transport	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier organic anion transporter family member 1B2

Names: liver-specific organic anion transporter 1; liver-specific transporter-1; organic anion transporting polypeptide 4; sodium-independent organic anion-transporting polypeptide 4; solute carrier family (organic anion transporter) member 10; solute carrier family 21 (organic anion transporter) member 10; solute carrier family 21 member 10; solute carrier organic anion transporter family, member 1b3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270586.1 → NP_001257515.1 solute carrier organic anion transporter family member 1B2 isoform 2

See identical proteins and their annotated locations for NP_001257515.1

Status: VALIDATED

Description

Transcript Variant: This variant (2, also known as rlst-1b) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AF147740, AF217450, JAXUCZ010000004

UniProtKB/TrEMBL

A6IMP2

Conserved Domains (4) summary

cd06174
Location:31 → 398

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:417 → 472

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

pfam03137
Location:29 → 580

OATP; Organic Anion Transporter Polypeptide (OATP) family

cl21472
Location:491 → 561

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
NM_001270587.1 → NP_001257516.1 solute carrier organic anion transporter family member 1B2 isoform 3

See identical proteins and their annotated locations for NP_001257516.1

Status: VALIDATED

Description

Transcript Variant: This variant (3, also known as rlst-1c) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AF217450, JAXUCZ010000004

UniProtKB/TrEMBL

A6IMP3

Related

ENSRNOP00000013514.4, ENSRNOT00000013514.8

Conserved Domains (4) summary

cd06174
Location:31 → 394

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:419 → 474

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

pfam03137
Location:29 → 582

OATP; Organic Anion Transporter Polypeptide (OATP) family

cl21472
Location:493 → 563

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
NM_031650.3 → NP_113838.1 solute carrier organic anion transporter family member 1B2 isoform 1

See identical proteins and their annotated locations for NP_113838.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AF208545, JAXUCZ010000004

UniProtKB/Swiss-Prot

Q9JHF6, Q9JIM2, Q9QZX8

UniProtKB/TrEMBL

A6IMP1

Related

ENSRNOP00000013409.4, ENSRNOT00000013409.9

Conserved Domains (1) summary

cl28910
Location:28 → 555

MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

176282577..176355557

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108300.2 → XP_038964228.1 solute carrier organic anion transporter family member 1B2 isoform X1

UniProtKB/Swiss-Prot

Q9JHF6, Q9JIM2, Q9QZX8

UniProtKB/TrEMBL

A6IMP1

Conserved Domains (1) summary

cl28910
Location:28 → 555

MFS; Major Facilitator Superfamily
XM_039108301.2 → XP_038964229.1 solute carrier organic anion transporter family member 1B2 isoform X2

UniProtKB/TrEMBL

A6IMP4

Conserved Domains (1) summary

pfam03137
Location:27 → 472

OATP; Organic Anion Transporter Polypeptide (OATP) family