Pole2 DNA polymerase epsilon 2, accessory subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pole2provided by RGD
Official Full Name: DNA polymerase epsilon 2, accessory subunitprovided by RGD
Primary source: RGD:1311962
See related: EnsemblRapid:ENSRNOG00000004242 AllianceGenome:RGD:1311962
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity. Predicted to be involved in DNA-templated DNA replication and error-prone translesion synthesis. Predicted to be located in nuclear body. Predicted to be part of epsilon DNA polymerase complex. Orthologous to human POLE2 (DNA polymerase epsilon 2, accessory subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 38.6), Thymus (RPKM 36.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (93410713..93448782, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (87674702..87712723, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (91494348..91532355, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated DNA replication	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in error-prone translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of epsilon DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of epsilon DNA polymerase complex	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA polymerase epsilon subunit 2

Names: polymerase (DNA directed), epsilon 2 (p59 subunit); polymerase (DNA directed), epsilon 2, accessory subunit; polymerase (DNA) epsilon 2, accessory subunit

NP_001162579.1

EC 2.7.7.7

XP_006240216.1

EC 2.7.7.7

XP_038967911.1

EC 2.7.7.7

XP_038967916.1

EC 2.7.7.7

XP_063117750.1

EC 2.7.7.7

XP_063117751.1

EC 2.7.7.7

XP_063117752.1

EC 2.7.7.7

XP_063117753.1

EC 2.7.7.7

XP_063117754.1

EC 2.7.7.7

XP_063117755.1

EC 2.7.7.7

XP_063117756.1

EC 2.7.7.7

XP_063117757.1

EC 2.7.7.7

XP_063117758.1

EC 2.7.7.7

XP_063117759.1

EC 2.7.7.7

XP_063117760.1

EC 2.7.7.7

XP_063117761.1

EC 2.7.7.7

XP_063117762.1

EC 2.7.7.7

XP_063117763.1

EC 2.7.7.7

XP_063117764.1

EC 2.7.7.7

XP_063117765.1

EC 2.7.7.7

XP_063117766.1

EC 2.7.7.7

XP_063117767.1

EC 2.7.7.7

XP_063117768.1

EC 2.7.7.7

XP_063117769.1

EC 2.7.7.7

XP_063117770.1

EC 2.7.7.7

XP_063117771.1

EC 2.7.7.7

XP_063117772.1

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001169108.1 → NP_001162579.1 DNA polymerase epsilon subunit 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6A566, D4ABZ5

Related

ENSRNOP00000005835.5, ENSRNOT00000005835.7

Conserved Domains (2) summary

pfam04042
Location:288 → 489

DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B

pfam12213
Location:3 → 73

Dpoe2NT; DNA polymerases epsilon N terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

93410713..93448782 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261701.1 → XP_063117771.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261686.1 → XP_063117756.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261697.1 → XP_063117767.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261699.1 → XP_063117769.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261698.1 → XP_063117768.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261696.1 → XP_063117766.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261685.1 → XP_063117755.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261687.1 → XP_063117757.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261695.1 → XP_063117765.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261702.1 → XP_063117772.1 DNA polymerase epsilon subunit 2 isoform X2
XM_039111988.2 → XP_038967916.1 DNA polymerase epsilon subunit 2 isoform X2

UniProtKB/TrEMBL

A0A8I6A566

Conserved Domains (1) summary

pfam04042
Location:228 → 429

DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
XM_063261688.1 → XP_063117758.1 DNA polymerase epsilon subunit 2 isoform X2
XM_039111983.2 → XP_038967911.1 DNA polymerase epsilon subunit 2 isoform X2

UniProtKB/TrEMBL

A0A8I6A566

Conserved Domains (1) summary

pfam04042
Location:228 → 429

DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
XM_063261680.1 → XP_063117750.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261690.1 → XP_063117760.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261700.1 → XP_063117770.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261684.1 → XP_063117754.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261693.1 → XP_063117763.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261681.1 → XP_063117751.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261692.1 → XP_063117762.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261694.1 → XP_063117764.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261682.1 → XP_063117752.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261691.1 → XP_063117761.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261689.1 → XP_063117759.1 DNA polymerase epsilon subunit 2 isoform X2
XM_063261683.1 → XP_063117753.1 DNA polymerase epsilon subunit 2 isoform X2
XM_006240154.5 → XP_006240216.1 DNA polymerase epsilon subunit 2 isoform X1

UniProtKB/TrEMBL

A0A8I6A566

Conserved Domains (2) summary

pfam04042
Location:288 → 488

DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B

pfam12213
Location:3 → 73

Dpoe2NT; DNA polymerases epsilon N terminal