Trpa1 transient receptor potential cation channel, subfamily A, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trpa1provided by RGD
Official Full Name: transient receptor potential cation channel, subfamily A, member 1provided by RGD
Primary source: RGD:1303284
See related: EnsemblRapid:ENSRNOG00000007354 AllianceGenome:RGD:1303284
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Anktm1
Summary: Enables osmolarity-sensing monoatomic cation channel activity and voltage-gated calcium channel activity. Involved in several processes, including cellular response to caffeine; cellular response to carbon dioxide; and positive regulation of transport. Located in apical plasma membrane and axon. Used to study asthma; diabetic neuropathy; and overactive bladder syndrome. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 9.3), Testes (RPKM 7.6) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q11

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (9163060..9217325)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (4379862..4434133)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (3783247..3836485)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ammonium chloride-induced hypothermia is attenuated by transient receptor potential channel vanilloid-1, but augmented by ankyrin-1 in rodents.
Title: Ammonium chloride-induced hypothermia is attenuated by transient receptor potential channel vanilloid-1, but augmented by ankyrin-1 in rodents.
Hypothalamic TRPM8 and TRPA1 ion channel genes in the regulation of temperature homeostasis at water balance changes.
Title: Hypothalamic TRPM8 and TRPA1 ion channel genes in the regulation of temperature homeostasis at water balance changes.
Transient receptor potential ankyrin 1 channels in the bladder mediate low temperature elicited bladder overactivity in rats.
Title: Transient receptor potential ankyrin 1 channels in the bladder mediate low temperature elicited bladder overactivity in rats.
Involvement of interaction of Cav3.2 and nociceptive TRPA1 in pathological pain transmission.
Title: Involvement of interaction of Cav3.2 and nociceptive TRPA1 in pathological pain transmission.
Functional expression of the thermally activated transient receptor potential channels TRPA1 and TRPM8 in human myotubes.
Title: Functional expression of the thermally activated transient receptor potential channels TRPA1 and TRPM8 in human myotubes.
TRPA1 deficiency attenuates cardiac fibrosis via regulating GRK5/NFAT signaling in diabetic rats.
Title: TRPA1 deficiency attenuates cardiac fibrosis via regulating GRK5/NFAT signaling in diabetic rats.
Activation of TRPA1 in Bladder Suburothelial Myofibroblasts Counteracts TGF-beta1-Induced Fibrotic Changes.
Title: Activation of TRPA1 in Bladder Suburothelial Myofibroblasts Counteracts TGF-β1-Induced Fibrotic Changes.
Ectopic endometriosis in the pelvic cavity evokes bladder hypersensitivity via transient receptor potential ankyrin 1 hyperexpression in rats.
Title: Ectopic endometriosis in the pelvic cavity evokes bladder hypersensitivity via transient receptor potential ankyrin 1 hyperexpression in rats.
TRPA1 deficiency aggravates dilated cardiomyopathy by promoting S100A8 expression to induce M1 macrophage polarization in rats.
Title: TRPA1 deficiency aggravates dilated cardiomyopathy by promoting S100A8 expression to induce M1 macrophage polarization in rats.
Non-neuronal TRPA1 encodes mechanical allodynia associated with neurogenic inflammation and partial nerve injury in rats.
Title: Non-neuronal TRPA1 encodes mechanical allodynia associated with neurogenic inflammation and partial nerve injury in rats.

Submit: New GeneRIF Correction See all GeneRIFs (139)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intracellularly gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables osmolarity-sensing monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables temperature-gated cation channel activity	ISO Inferred from Sequence Orthology more info
enables temperature-gated cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane import into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane import into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to caffeine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to carbon dioxide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in detection of mechanical stimulus involved in sensory perception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monoatomic anion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood circulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	ISO Inferred from Sequence Orthology more info
involved_in response to cold	ISO Inferred from Sequence Orthology more info
involved_in response to cold	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within thermoception	ISO Inferred from Sequence Orthology more info
involved_in urinary bladder smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in stereocilium bundle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transient receptor potential cation channel subfamily A member 1

Names: ankyrin-like with transmembrane domains protein 1; wasabi receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207608.2 → NP_997491.2 transient receptor potential cation channel subfamily A member 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

F1LRH9, Q6RI86

UniProtKB/TrEMBL

A0A8I6AD92

Related

ENSRNOP00000009874.2, ENSRNOT00000009874.4