Tbce tubulin folding cofactor E [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tbceprovided by RGD
Official Full Name: tubulin folding cofactor Eprovided by RGD
Primary source: RGD:1305533
See related: EnsemblRapid:ENSRNOG00000029667 AllianceGenome:RGD:1305533
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable alpha-tubulin binding activity. Predicted to be involved in mitotic spindle organization; post-chaperonin tubulin folding pathway; and tubulin complex assembly. Predicted to act upstream of or within several processes, including adult locomotory behavior; muscle atrophy; and peripheral nervous system neuron axonogenesis. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Kenny-Caffey syndrome type 1; hypoparathyroidism; and hypoparathyroidism-retardation-dysmorphism syndrome. Orthologous to human TBCE (tubulin folding cofactor E). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 226.7), Thymus (RPKM 220.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (55983627..56031578)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (51290143..51336090)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (53983126..54029028)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AA998918 (e-PCR)
- UniSTS:248633

AU048913 (e-PCR)
- UniSTS:145363

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in developmental growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within developmental growth	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in muscle atrophy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle atrophy	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system neuron axonogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peripheral nervous system neuron axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in post-chaperonin tubulin folding pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-chaperonin tubulin folding pathway	IEA Inferred from Electronic Annotation more info
involved_in post-chaperonin tubulin folding pathway	ISO Inferred from Sequence Orthology more info
involved_in post-chaperonin tubulin folding pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in tubulin complex assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tubulin-specific chaperone E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012161.1 → NP_001012161.1 tubulin-specific chaperone E

See identical proteins and their annotated locations for NP_001012161.1

Status: PROVISIONAL

Source sequence(s)

BC089833

UniProtKB/Swiss-Prot

Q5FVQ9

UniProtKB/TrEMBL

A0A8I5ZRE1, A6K9D0

Related

ENSRNOP00000042689.4, ENSRNOT00000040743.6

Conserved Domains (5) summary

smart01052
Location:10 → 73

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

sd00033
Location:156 → 180

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:129 → 142

LRR_AMN1; leucine-rich repeat [structural motif]

pfam13855
Location:230 → 287

LRR_8; Leucine rich repeat

cl00155
Location:443 → 522

UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

55983627..56031578

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254015.5 → XP_006254077.1 tubulin-specific chaperone E isoform X3

See identical proteins and their annotated locations for XP_006254077.1

UniProtKB/TrEMBL

A0A8I5ZRE1

Conserved Domains (4) summary

smart01052
Location:10 → 73

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

sd00033
Location:156 → 180

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:129 → 142

LRR_AMN1; leucine-rich repeat [structural motif]

pfam13855
Location:230 → 287

LRR_8; Leucine rich repeat
XM_063276619.1 → XP_063132689.1 tubulin-specific chaperone E isoform X1

UniProtKB/TrEMBL

A0A8I5ZRE1

Related

ENSRNOP00000099959.1, ENSRNOT00000150216.1
XM_063276620.1 → XP_063132690.1 tubulin-specific chaperone E isoform X2

UniProtKB/TrEMBL

A0A0G2K191, A0A8I5ZRE1

Related

ENSRNOP00000071747.1, ENSRNOT00000079433.3
XM_063276622.1 → XP_063132692.1 tubulin-specific chaperone E isoform X4
XM_063276623.1 → XP_063132693.1 tubulin-specific chaperone E isoform X5
XM_063276621.1 → XP_063132691.1 tubulin-specific chaperone E isoform X2

UniProtKB/TrEMBL

A0A0G2K191, A0A8I5ZRE1
XM_017600614.3 → XP_017456103.1 tubulin-specific chaperone E isoform X3

UniProtKB/TrEMBL

A0A8I5ZRE1

Conserved Domains (4) summary

smart01052
Location:10 → 73

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

sd00033
Location:156 → 180

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:129 → 142

LRR_AMN1; leucine-rich repeat [structural motif]

pfam13855
Location:230 → 287

LRR_8; Leucine rich repeat
XM_039095911.1 → XP_038951839.1 tubulin-specific chaperone E isoform X6

Conserved Domains (3) summary

sd00033
Location:4 → 28

LRR_RI; leucine-rich repeat [structural motif]

cd17044
Location:289 → 342

Ubl_TBCE; ubiquitin-like (Ubl) domain found in tubulin-folding cofactor E (TBCE) and similar proteins

cd21340
Location:80 → 224

PPP1R42; protein phosphatase 1 regulatory subunit 42