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    atg13 ATG13 autophagy related 13 homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

    Gene ID: 393405, updated on 5-Jan-2025

    Summary

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    Official Symbol
    atg13provided by ZNC
    Official Full Name
    ATG13 autophagy related 13 homolog (S. cerevisiae)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1149
    See related
    Ensembl:ENSDARG00000036040 AllianceGenome:ZFIN:ZDB-GENE-040426-1149
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63526
    Summary
    Predicted to enable protein kinase regulator activity. Acts upstream of or within positive regulation of chondrocyte proliferation; regulation of autophagy; and regulation of chondrocyte development. Predicted to be located in cytoplasm. Predicted to be part of Atg1/ULK1 kinase complex. Predicted to be active in autophagosome; cytosol; and phagophore assembly site. Orthologous to human ATG13 (autophagy related 13). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See atg13 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (38793833..38807824, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (38522575..38536585, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 1 Neighboring gene si:dkey-23n7.10 Neighboring gene zgc:110699 Neighboring gene harbinger transposase derived 1 Neighboring gene PHD finger protein 21Aa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Autophagy coordinates chondrocyte development and early joint formation in zebrafish. Moss JJ, et al. FASEB J, 2021 Nov. PMID 34708458, Free PMC Article
    2. Stimulating the autophagic-lysosomal axis enhances host defense against fungal infection in a zebrafish model of invasive Aspergillosis. Forn-Cuní G, et al. Autophagy, 2023 Jan. PMID 35775203, Free PMC Article
    3. Distinct roles of core autophagy-related genes in zebrafish definitive hematopoiesis. Chen XK, et al. Autophagy, 2024 Apr. PMID 37921505, Free PMC Article
    4. Starvation stress affects the maternal development and larval fitness in zebrafish (Danio rerio). Fan X, et al. Sci Total Environ, 2019 Dec 10. PMID 31425978
    5. Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish. Feng N, et al. Singapore Med J, 2019 May. PMID 30402654, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC63526

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of chondrocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of chondrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Atg1/ULK1 kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Atg1/ULK1 kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    autophagy-related protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200433.2 → NP_956727.1  autophagy-related protein 13

      See identical proteins and their annotated locations for NP_956727.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054904
      UniProtKB/Swiss-Prot
      Q7SYE0
      Related
      ENSDARP00000052323.3, ENSDART00000052324.6
      Conserved Domains (1) summary
      pfam10033
      Location:19 → 192
      ATG13; Autophagy-related protein 13

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      38793833..38807824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168970.5 → XP_005169027.1  autophagy-related protein 13 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BG96
      Conserved Domains (1) summary
      pfam10033
      Location:19 → 192
      ATG13; Autophagy-related protein 13
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SYE0.1 GenPept UniProtKB/Swiss-Prot:Q7SYE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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