arhgap1 Rho GTPase activating protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arhgap1provided by ZNC
Official Full Name: Rho GTPase activating protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-305
See related: Ensembl:ENSDARG00000024324 AllianceGenome:ZFIN:ZDB-GENE-050417-305
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fk03b12; fk61c06; wu:fk03b12; wu:fk61c06; zgc:110361; wu:cegs2891
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of endocytic recycling and small GTPase-mediated signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm. Is expressed in female organism; musculature system; nervous system; and somite. Orthologous to human ARHGAP1 (Rho GTPase activating protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (38762078..38783614)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (38490820..38512356)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rho is activated in a discrete apical region of premigratory neural crest cells. Arhgap1 restricts Rho activation to apical areas, and this restriction is necessary for detachment.
Title: Rho activation is apically restricted by Arhgap1 in neural crest cells and drives epithelial-to-mesenchymal transition.

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General gene information

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Markers

fk03b12.x1 (e-PCR)
- UniSTS:200497

fk61c06.x1 (e-PCR)
- UniSTS:201299

fj03g08.y1 (e-PCR)
- UniSTS:198328

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho GTPase-activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017781.1 → NP_001017781.1 rho GTPase-activating protein 1

See identical proteins and their annotated locations for NP_001017781.1

Status: PROVISIONAL

Source sequence(s)

BC092897

UniProtKB/TrEMBL

Q568D8

Related

ENSDARP00000034827.5, ENSDART00000036461.6

Conserved Domains (2) summary

cd04404
Location:238 → 432

RhoGAP-p50rhoGAP; RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol ...

pfam13716
Location:82 → 204

CRAL_TRIO_2; Divergent CRAL/TRIO domain