psmc1a proteasome 26S subunit, ATPase 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: psmc1aprovided by ZNC
Official Full Name: proteasome 26S subunit, ATPase 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8730
See related: Ensembl:ENSDARG00000030537 AllianceGenome:ZFIN:ZDB-GENE-030131-8730
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: psmc1; zgc:56516; wu:fb05d04
Summary: Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss. Orthologous to human PSMC1 (proteasome 26S subunit, ATPase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (8925751..8941421)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (8768571..8784241)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb05d04.x1 (e-PCR)
- UniSTS:189892

AI331144 (e-PCR)
- UniSTS:206800

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proteasome 26S subunit, ATPase 1a

Names: proteasome (prosome, macropain) 26S subunit, ATPase, 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200033.1 → NP_956327.1 proteasome 26S subunit, ATPase 1a

See identical proteins and their annotated locations for NP_956327.1

Status: PROVISIONAL

Source sequence(s)

BC049471

UniProtKB/TrEMBL

Q7ZWD1

Related

ENSDARP00000030555.5, ENSDART00000036668.6

Conserved Domains (3) summary

PTZ00361
Location:25 → 440

PTZ00361; 26 proteosome regulatory subunit 4-like protein; Provisional

pfam00004
Location:222 → 355

AAA; ATPase family associated with various cellular activities (AAA)

pfam16450
Location:108 → 176

Prot_ATP_ID_OB; Proteasomal ATPase OB/ID domain