gatb glutamyl-tRNA(Gln) amidotransferase, subunit B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gatbprovided by ZNC
Official Full Name: glutamyl-tRNA(Gln) amidotransferase, subunit Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040724-131
See related: Ensembl:ENSDARG00000037309 AllianceGenome:ZFIN:ZDB-GENE-040724-131
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pet112; Pet112l; zC150A22.1; zgc:103736; si:ch211-150a22.1
Summary: Predicted to enable glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Predicted to be involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Predicted to act upstream of or within translation. Predicted to be part of glutamyl-tRNA(Gln) amidotransferase complex. Predicted to be active in mitochondrion. Is expressed in serotonergic neurons. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 41. Orthologous to human GATB (glutamyl-tRNA amidotransferase subunit B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (24520503..24557267, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (23829674..23866438, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables carbon-nitrogen ligase activity, with glutamine as amido-N-donor	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutaminyl-tRNAGln biosynthesis via transamidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of glutamyl-tRNA(Gln) amidotransferase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

Names: PET112-like; cytochrome c oxidase assembly factor PET112 homolog; glu-AdT subunit B; glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial-like

NP_001013464.2

EC 6.3.5.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013446.3 → NP_001013464.2 glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

See identical proteins and their annotated locations for NP_001013464.2

Status: VALIDATED

Source sequence(s)

AL772332, CT573492

UniProtKB/Swiss-Prot

Q7T010

Related

ENSDARP00000093298.3, ENSDART00000102522.4

Conserved Domains (3) summary

smart00845
Location:404 → 552

GatB_Yqey; GatB domain

PRK05477
Location:62 → 552

gatB; aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated

pfam02934
Location:62 → 344

GatB_N; GatB/GatE catalytic domain