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    fahd2a fumarylacetoacetate hydrolase domain containing 2A [ Danio rerio (zebrafish) ]

    Gene ID: 405854, updated on 4-Jan-2025

    Summary

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    Official Symbol
    fahd2aprovided by ZNC
    Official Full Name
    fumarylacetoacetate hydrolase domain containing 2Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2499
    See related
    Ensembl:ENSDARG00000103759 AllianceGenome:ZFIN:ZDB-GENE-040426-2499
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:85683
    Summary
    Predicted to enable hydrolase activity. Is expressed in yolk syncytial layer. Orthologous to human FAHD2A (fumarylacetoacetate hydrolase domain containing 2A) and FAHD2B (fumarylacetoacetate hydrolase domain containing 2B). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human all
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    Genomic context

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    See fahd2a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (41186027..41228531, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (41152055..41194562, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110440018 Neighboring gene glycerol-3-phosphate acyltransferase 2, mitochondrial Neighboring gene zgc:152830 Neighboring gene ring finger protein 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC85683

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    fumarylacetoacetate hydrolase domain-containing protein 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212918.1 → NP_998083.1  fumarylacetoacetate hydrolase domain-containing protein 2A

      See identical proteins and their annotated locations for NP_998083.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067576
      UniProtKB/TrEMBL
      Q6NWI6
      Related
      ENSDARP00000141900.1, ENSDART00000165949.2
      Conserved Domains (2) summary
      COG0179
      Location:23 → 289
      MhpD; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]
      pfam01557
      Location:84 → 288
      FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      41186027..41228531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222910.1 → XP_068079011.1  fumarylacetoacetate hydrolase domain-containing protein 2A isoform X5

      UniProtKB/TrEMBL
      A0A8M9Q9M2

    2. XM_021478228.2 → XP_021333903.1  fumarylacetoacetate hydrolase domain-containing protein 2A isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q3D7
      Conserved Domains (1) summary
      COG0179
      Location:53 → 319
      MhpD; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]

    3. XM_021478226.2 → XP_021333901.1  fumarylacetoacetate hydrolase domain-containing protein 2A isoform X1

      UniProtKB/TrEMBL
      A0A8M9QDP1
      Conserved Domains (1) summary
      COG0179
      Location:53 → 300
      MhpD; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]

    4. XM_068222909.1 → XP_068079010.1  fumarylacetoacetate hydrolase domain-containing protein 2A isoform X4

    5. XM_021478227.2 → XP_021333902.1  fumarylacetoacetate hydrolase domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      A0A8M9PQS6
      Conserved Domains (1) summary
      COG0179
      Location:51 → 298
      MhpD; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]
    Nucleotide Protein Strain
    Heading Accession and Version

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