opn1sw2 opsin 1 (cone pigments), short-wave-sensitive 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: opn1sw2provided by ZNC
Official Full Name: opsin 1 (cone pigments), short-wave-sensitive 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-990604-40
See related: Ensembl:ENSDARG00000017274 AllianceGenome:ZFIN:ZDB-GENE-990604-40
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: SWS2; bluops; zfblue; SI:zK13A21.5
Summary: Predicted to enable G protein-coupled photoreceptor activity. Acts upstream of or within detection of visible light and phototaxis. Located in photoreceptor outer segment. Is expressed in several structures, including endocrine system; heart; integument; photoreceptor cell; and visual system. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (25472758..25475403)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (25235161..25237787)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of SWS2 in zebrafish (Danio rerio) reveals its roles in feeding and phototactic behaviors.
Title: Knockout of SWS2 in zebrafish (Danio rerio) reveals its roles in feeding and phototactic behaviors.
Six6b and six7 govern expression of the SWS2 and RH2 opsins responsible for middle-wavelength sensitivity.
Title: Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish.
found a 0.3-kb region between 0.6 and 0.3 kb 5' of the SWS2 initiation codon, encompassing four cone-rod homeobox-binding sites (OTX sequences)
Title: Identification of cis-acting elements repressing blue opsin expression in zebrafish UV cones and pineal cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled photoreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables photoreceptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detection of visible light	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phototaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phototransduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: opsin-1, short-wave-sensitive 2

Names: blue cone opsin; blue cone photoreceptor pigment; blue-sensitive opsin; opsin SWS-2; short-wavelength-sensitive-2 cone opsin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131192.2 → NP_571267.1 opsin-1, short-wave-sensitive 2

See identical proteins and their annotated locations for NP_571267.1

Status: VALIDATED

Source sequence(s)

CT573282

UniProtKB/Swiss-Prot

Q9W6A8

UniProtKB/TrEMBL

A8E5J4

Related

ENSDARP00000019477.8, ENSDART00000011178.9

Conserved Domains (2) summary

pfam00001
Location:62 → 313

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:129 → 331

7tm_4; Olfactory receptor