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    Adgra1 adhesion G protein-coupled receptor A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309097, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgra1provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor A1provided by RGD
    Primary source
    RGD:1308241
    See related
    EnsemblRapid:ENSRNOG00000054955 AllianceGenome:RGD:1308241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr123
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in glutamatergic synapse and postsynaptic density. Orthologous to human ADGRA1 (adhesion G protein-coupled receptor A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 59.0), Adrenal (RPKM 12.7) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adgra1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (204059218..204102869)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (194629744..194673254)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (212170190..212213156)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485197 Neighboring gene uncharacterized LOC134484917 Neighboring gene kinase non-catalytic C-lobe domain containing 1 Neighboring gene uncharacterized LOC134485199 Neighboring gene undifferentiated embryonic cell transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Correlation profiling of brain sub-cellular proteomes reveals co-assembly of synaptic proteins and subcellular distribution. Pandya NJ, et al. Sci Rep, 2017 Sep 21. PMID 28935861, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 123; adhesion G protein-coupled receptor A1
    Names
    G protein-coupled receptor 123

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432263.1 → NP_001419192.1  probable G-protein coupled receptor 123

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K4I3, A6HXC5

    2. NM_001432264.1 → NP_001419193.1  probable G-protein coupled receptor 123

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K4I3, A6HXC5

    RNA

    1. NR_197277.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      204059218..204102869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101254.2 → XP_038957182.1  adhesion G protein-coupled receptor A1 isoform X1

      Conserved Domains (2) summary
      cd14964
      Location:19 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 328
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_039101255.2 → XP_038957183.1  adhesion G protein-coupled receptor A1 isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:135 → 152
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:135 → 325
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_039101253.2 → XP_038957181.1  adhesion G protein-coupled receptor A1 isoform X1

      Related
      ENSRNOP00000073055.2, ENSRNOT00000085921.3
      Conserved Domains (2) summary
      cd14964
      Location:19 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 328
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107559.1: Suppressed sequence

      Description
      NM_001107559.1: This RefSeq was temporarily suppressed because there is insufficient transcript data. The RefSeq cannot be derived from the draft reference genomic sequence because it contains a gap such that the correct protein cannot be represented.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials