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    Gnb1l G protein subunit beta 1 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680266, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gnb1lprovided by RGD
    Official Full Name
    G protein subunit beta 1 likeprovided by RGD
    Primary source
    RGD:1594165
    See related
    EnsemblRapid:ENSRNOG00000001891 AllianceGenome:RGD:1594165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in DNA damage checkpoint signaling. Predicted to act upstream of or within social behavior. Predicted to be located in cytoplasm and nucleus. Orthologous to human GNB1L (G protein subunit beta 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 12.7), Thymus (RPKM 10.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gnb1l in Genome Data Viewer
    Location:
    11q23
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (95933994..96011933, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82425301..82507836, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86575229..86655614, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481101 Neighboring gene T-box transcription factor 1 Neighboring gene uncharacterized LOC120095703 Neighboring gene thioredoxin reductase 2 Neighboring gene catechol-O-methyltransferase Neighboring gene ARVCF, delta catenin family member Neighboring gene small Cajal body-specific RNA 14 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Paylor R, et al. Proc Natl Acad Sci U S A, 2006 May 16. PMID 16684884, Free PMC Article
    2. Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes. Maynard TM, et al. Mol Cell Neurosci, 2008 Nov. PMID 18775783, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within social behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein subunit beta-like protein 1
    Names
    guanine nucleotide binding protein (G protein), beta polypeptide 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398877.1 → NP_001385806.1  guanine nucleotide-binding protein subunit beta-like protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      D4A2F0, M0R4I1
      Related
      ENSRNOP00000064268.2, ENSRNOT00000073377.4
      Conserved Domains (2) summary
      sd00039
      Location:24 → 64
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:12 → 321
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      95933994..96011933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248654.5 → XP_006248716.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006248716.1

      Conserved Domains (3) summary
      COG2319
      Location:14 → 289
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:23 → 64
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:12 → 288
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_039088981.2 → XP_038944909.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X1

      UniProtKB/TrEMBL
      D4A2F0, M0R4I1
      Conserved Domains (2) summary
      sd00039
      Location:24 → 64
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:12 → 321
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_017598200.2 → XP_017453689.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X2

      Related
      ENSRNOP00000102738.1, ENSRNOT00000141470.1

    4. XM_039088982.1 → XP_038944910.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X4

      Conserved Domains (2) summary
      sd00039
      Location:108 → 147
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:71 → 219
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_005491494.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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