Aqp11 aquaporin 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aqp11provided by RGD
Official Full Name: aquaporin 11provided by RGD
Primary source: RGD:628763
See related: EnsemblRapid:ENSRNOG00000013358 AllianceGenome:RGD:628763
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables identical protein binding activity. Predicted to be involved in several processes, including glycerol transmembrane transport; hydrogen peroxide transmembrane transport; and intracellular oxygen homeostasis. Predicted to act upstream of or within with a positive effect on protein glycosylation. Predicted to act upstream of or within endosomal lumen acidification and kidney development. Located in cell surface and dendrite. Orthologous to human AQP11 (aquaporin 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 572.2), Kidney (RPKM 88.9) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (161457752..161467918, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (152046515..152056675, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (162703394..162713560, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of AQP-10, -11 and -12 in the rat stria vascularis.
Title: Expression of AQP-10, -11 and -12 in the rat stria vascularis.
application of exogenous miR-27a-3p may protect against post-ICH complications by targeting AQP11 in the capillary endothelial cells of the brain.
Title: miR-27a-3p protects against blood-brain barrier disruption and brain injury after intracerebral hemorrhage by targeting endothelial aquaporin-11.
Immunohistochemistry of adult testis & epididymal sperm localized AQP11 to elongated spermatids, residual bodies of Sertoli cells, & distal sperm tail. cDNA analysis yielded conformation of sequence. Western blotting revealed additional forms.
Title: Aquaporin AQP11 in the testis: molecular identity and association with the processing of residual cytoplasm of elongated spermatids.
AQP11 has a unique distribution in brain: Purkinje cell dendrites, CA1 & CA2 neurons, & cerebral cortical neurons. It is functionally distinct from other proteins of the aquaporin superfamily and could represent a new aquaporin subfamily.
Title: Aquaporin-11: a channel protein lacking apparent transport function expressed in brain.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables channel activity	IEA Inferred from Electronic Annotation more info
enables glycerol channel activity	IEA Inferred from Electronic Annotation more info
enables glycerol channel activity	ISO Inferred from Sequence Orthology more info
enables glycerol channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrogen peroxide channel activity	IEA Inferred from Electronic Annotation more info
enables hydrogen peroxide channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables water channel activity	IEA Inferred from Electronic Annotation more info
enables water channel activity	ISO Inferred from Sequence Orthology more info
enables water channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within endosomal lumen acidification	ISO Inferred from Sequence Orthology more info
NOT involved_in glycerol transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerol transmembrane transport	IEA Inferred from Electronic Annotation more info
NOT involved_in glycerol transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in glycerol transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in glycerol transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in hydrogen peroxide transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in hydrogen peroxide transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular oxygen homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular water homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular water homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
NOT involved_in monoatomic ion transport	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_positive_effect protein glycosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect protein glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proximal tubule development	ISO Inferred from Sequence Orthology more info
involved_in proximal tubule development	ISO Inferred from Sequence Orthology more info
involved_in proximal tubule development	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
NOT involved_in urea transport	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in urea transport	ISO Inferred from Sequence Orthology more info
NOT involved_in water transport	IDA Inferred from Direct Assay more info	PubMed
involved_in water transport	IEA Inferred from Electronic Annotation more info
NOT involved_in water transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within water transport	ISO Inferred from Sequence Orthology more info
involved_in water transport	ISO Inferred from Sequence Orthology more info
involved_in water transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
NOT located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aquaporin-11

Names: AQP-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173105.1 → NP_775128.1 aquaporin-11

See identical proteins and their annotated locations for NP_775128.1

Status: PROVISIONAL

Source sequence(s)

AB023644

UniProtKB/Swiss-Prot

Q6AZ79, Q8CHM1

UniProtKB/TrEMBL

A6I6B5

Related

ENSRNOP00000018091.5, ENSRNOT00000018091.7

Conserved Domains (1) summary

cl00200
Location:46 → 257

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...