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    Glis1 GLIS family zinc finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298732, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Glis1provided by RGD
    Official Full Name
    GLIS family zinc finger 1provided by RGD
    Primary source
    RGD:1308030
    See related
    EnsemblRapid:ENSRNOG00000000138 AllianceGenome:RGD:1308030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including fat cell differentiation; osteoblast differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human GLIS1 (GLIS family zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 27.1), Spleen (RPKM 5.8) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Glis1 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (127450934..127640929)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (122222155..122412141)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (127043344..127233395)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene Yip1 domain family, member 1 Neighboring gene NDC1 transmembrane nucleoporin Neighboring gene uncharacterized LOC102551042 Neighboring gene uncharacterized LOC120102948 Neighboring gene uncharacterized LOC134486961 Neighboring gene uncharacterized LOC102551560 Neighboring gene DMRT-like family B with proline-rich C-terminal, 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Temporal enhancer profiling of parallel lineages identifies AHR and GLIS1 as regulators of mesenchymal multipotency. Gérard D, et al. Nucleic Acids Res, 2019 Feb 20. PMID 30544251, Free PMC Article
    2. Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions. Kim YS, et al. J Biol Chem, 2002 Aug 23. PMID 12042312
    3. A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development. Nakashima M, et al. Mech Dev, 2002 Nov. PMID 12385751
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein GLIS1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106703.2 → NP_001100173.2  zinc finger protein GLIS1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JYS2, F1LVY3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      127450934..127640929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238561.4 → XP_006238623.1  zinc finger protein GLIS1 isoform X1

      Related
      ENSRNOP00000104107.1, ENSRNOT00000165226.1
      Conserved Domains (3) summary
      COG5048
      Location:435 → 514
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:439 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:453 → 480
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039111146.2 → XP_038967074.1  zinc finger protein GLIS1 isoform X2

      Related
      ENSRNOP00000036043.8, ENSRNOT00000032433.9
      Conserved Domains (2) summary
      COG5048
      Location:435 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:439 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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