Wnt11 Wnt family member 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wnt11provided by RGD
Official Full Name: Wnt family member 11provided by RGD
Primary source: RGD:621463
See related: EnsemblRapid:ENSRNOG00000015982 AllianceGenome:RGD:621463
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine activity; frizzled binding activity; and protein kinase activator activity. Involved in cell differentiation and response to nutrient levels. Predicted to be located in cytoplasm; extracellular matrix; and extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human WNT11 (Wnt family member 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 33.3), Heart (RPKM 23.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (162545660..162565456)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (153134503..153154294)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (163794136..163813756)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WNT11-Conditioned Medium Promotes Angiogenesis through the Activation of Non-Canonical WNT-PKC-JNK Signaling Pathway.
Title: WNT11-Conditioned Medium Promotes Angiogenesis through the Activation of Non-Canonical WNT-PKC-JNK Signaling Pathway.
the pathogenesis of calcium stone development may be associated with synergic effects of TGF-beta1 and Ca2+, which promote epithelial to mesenchymal transition and osteochondral differentiation via Wnt11 and the L-type calcium channel.
Title: The Wnt11 Signaling Pathway in Potential Cellular EMT and Osteochondral Differentiation Progression in Nephrolithiasis Formation.
Wnt11 overexpression promoted chondrogenic differentiation of MSCs in synergism with TGF-beta
Title: Overexpression of Wnt11 promotes chondrogenic differentiation of bone marrow-derived mesenchymal stem cells in synergism with TGF-β.
Wnt11 expression in rat dental pulp and promotional effects of Wnt signaling on odontoblast differentiation.
Title: Wnt11 expression in rat dental pulp and promotional effects of Wnt signaling on odontoblast differentiation.
Wnt11 may be involved in the spheroid formation and cardiomyogenic differentiation of mesenchymal stem cells on chitosan membranes.
Title: The calcium-dependent regulation of spheroid formation and cardiomyogenic differentiation for MSCs on chitosan membranes.
demonstrates that the combination of Wnt11 and BMP-2 effectively promotes cardiomyogenic differentiation of BM-MSCs in vitro. The synergistic effect of Wnt11 and BMP-2 on the cardiomyogenic differentiation of BM-MSCs is further enhanced in myocardium
Title: Efficient cardiomyogenic differentiation of bone marrow mesenchymal stromal cells by combination of Wnt11 and bone morphogenetic protein 2.
Wnt11 stimulates proliferation, migration, cytoskeletal rearrangement, and contact-independent growth by a beta-catenin-independent mechanism
Title: Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells.

Submit: New GeneRIF Correction

General gene information

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Markers

Wnt11 (e-PCR), detects polymorphism
- UniSTS:465417

Wnt11 (e-PCR), detects polymorphism
- UniSTS:526098

UniSTS:471854 (e-PCR)
- UniSTS:471854

Wnt11 (e-PCR), detects polymorphism
- UniSTS:471854

RP_L27 (e-PCR)
- UniSTS:34017

D1Mgh8 (e-PCR)
- UniSTS:118499

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adrenal gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in atrial septum development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cloacal septation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within convergent extension involved in axis elongation	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in lung-associated mesenchyme development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maintenance of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in mesonephric duct development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fibroblast growth factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuroendocrine cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within notochord morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within paraxial mesoderm formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transforming growth factor beta2 production	ISO Inferred from Sequence Orthology more info
involved_in primary heart field specification	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in secondary heart field specification	ISO Inferred from Sequence Orthology more info
involved_in secondary palate development	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somite development	ISO Inferred from Sequence Orthology more info
acts_upstream_of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-11

Names: wingless-related MMTV integration site 11; wingless-type MMTV integration site family, member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080401.1 → NP_536326.1 protein Wnt-11

See identical proteins and their annotated locations for NP_536326.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6I6F2, G3V819

Conserved Domains (1) summary

cd19343
Location:51 → 354

Wnt_Wnt11; Wnt domain found in protein Wnt-11 and similar proteins