ECM29 Ecm29p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: ECM29
Official Full Name: Ecm29p
Primary source: SGD:S000001022
Locus tag: YHL030W
See related: AllianceGenome:SGD:S000001022; FungiDB:YHL030W; VEuPathDB:YHL030W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ATPase inhibitor activity and molecular adaptor activity. Involved in proteasome assembly. Located in nucleus. Part of proteasome complex. Orthologous to human ECPAS (Ecm29 proteasome adaptor and scaffold). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

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Ecm29 requires the phosphorylated tail of the proteasome subunit alpha7 for its association with proteasomes.
Title: Phosphorylation of the C-terminal tail of proteasome subunit α7 is required for binding of the proteasome quality control factor Ecm29.
Data show that Ecm29 acts as a proteasome inhibitor.
Title: The proteasome-associated protein Ecm29 inhibits proteasomal ATPase activity and in vivo protein degradation by the proteasome.
Loss of Rpt5 protein interactions with the core particle and Nas2 protein causes the formation of faulty proteasomes that are inhibited by Ecm29 protein.
Title: Loss of Rpt5 protein interactions with the core particle and Nas2 protein causes the formation of faulty proteasomes that are inhibited by Ecm29 protein.
results characterize Ecm29 as a proteasome chaperone whose appropriate interaction with the proteasome requires Not4
Title: Not4 E3 ligase contributes to proteasome assembly and functional integrity in part through Ecm29.
Studies indicate that deletion of ECM29 prevented the disassembly of the 26S proteasome in response to oxidative stress, and ecm29 mutants were more sensitive to HO than were wild-type cells.
Title: Regulation of the 26S proteasome complex during oxidative stress.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATPase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	IEA Inferred from Electronic Annotation more info

NP_011833.1

Scaffold protein; assists in association of proteasome core particle with regulatory particle; inhibitor of proteasome in vivo and in vitro; inhibits proteasomal ATPase activity; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress

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The following sections contain reference sequences that belong to a specific genome build. Explain