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    SPC105 Spc105p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPC105
    Official Full Name
    Spc105p
    Primary source
    SGD:S000003061
    Locus tag
    YGL093W
    See related
    AllianceGenome:SGD:S000003061; FungiDB:YGL093W; VEuPathDB:YGL093W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables microtubule binding activity. Involved in mitotic spindle assembly checkpoint signaling; protein localization to kinetochore; and sister chromatid biorientation. Located in kinetochore. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SPC105 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (334886..337639)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Vps45p Neighboring gene poly(A)-specific ribonuclease Neighboring gene nucleocytoplasmic transporter NUP145 Neighboring gene Fe-S cluster-binding ATPase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling. Aravamudhan P, et al. Nat Cell Biol, 2015 Jul. PMID 26053220, Free PMC Article
    2. Unattached kinetochores drive their own capturing by sequestering a CLASP. Kolenda C, et al. Nat Commun, 2018 Feb 28. PMID 29491436, Free PMC Article
    3. Kre28-Spc105 interaction is essential for Spc105 loading at the kinetochore. Roy B, et al. Open Biol, 2022 Jan. PMID 35042402, Free PMC Article
    4. The copy-number and varied strengths of MELT motifs in Spc105 balance the strength and responsiveness of the spindle assembly checkpoint. Roy B, et al. Elife, 2020 Jun 1. PMID 32479259, Free PMC Article
    5. Killing two birds with one stone: how budding yeast Mps1 controls chromosome segregation and spindle assembly checkpoint through phosphorylation of a single kinetochore protein. Benzi G, et al. Curr Genet, 2020 Dec. PMID 32632756

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kre28-Spc105 interaction is essential for Spc105 loading at the kinetochore.
      Title: Kre28-Spc105 interaction is essential for Spc105 loading at the kinetochore.
    2. Killing two birds with one stone: how budding yeast Mps1 controls chromosome segregation and spindle assembly checkpoint through phosphorylation of a single kinetochore protein.
      Title: Killing two birds with one stone: how budding yeast Mps1 controls chromosome segregation and spindle assembly checkpoint through phosphorylation of a single kinetochore protein.
    3. recruitment of PP1 to Spc105/Knl1 is carefully regulated to ensure that chromosome recruitment of PP1 to Spc105/Knl1 is carefully regulated to ensure that chromosome biorientation precedes SAC silencing, thereby ensuring accurate chromosome segregationprecedes SAC silencing, thereby ensuring accurate chromosome segregation
      Title: Delineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation.
    4. Cnn1 regulates KMN (KNL1, MIS12 and NDC80 activity in a spatiotemporal manner by inhibiting the interaction between its complexes
      Title: Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore.
    5. the spc105p/kre28p complex has roles in kinetochore-microtubule binding and the spindle assembly checkpoint
      Title: Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic sister chromatid biorientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to kinetochore IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in sister chromatid biorientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spc105p
    NP_011422.1
    • Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Kre28p; modified by sumoylation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      334886..337639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180958.1 → NP_011422.1  TPA: Spc105p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011422.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU52, P53148
      UniProtKB/TrEMBL
      A6ZU87, C7GW25, C8Z8F5, N1P1U6
      Conserved Domains (2) summary
      smart00787
      Location:450 → 756
      Spc7; Spc7 kinetochore protein
      pfam15402
      Location:70 → 424
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53148.1

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