SEC16 Sec16p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SEC16
Official Full Name: Sec16p
Primary source: SGD:S000006006
Locus tag: YPL085W
See related: AllianceGenome:SGD:S000006006; FungiDB:YPL085W; VEuPathDB:YPL085W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LPF1
Summary: Enables protein-membrane adaptor activity. Involved in COPII vesicle coating; macroautophagy; and protein localization to endoplasmic reticulum exit site. Located in ER to Golgi transport vesicle membrane and endoplasmic reticulum exit site. Orthologous to several human genes including CRYZL2P-SEC16B (CRYZL2P-SEC16B readthrough) and SEC16B (SEC16 homolog B, endoplasmic reticulum export factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SEC16 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (387067..393654)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sec16 function in ER export and autophagy is independent of its phosphorylation in Saccharomyces cerevisiae.
Title: Sec16 function in ER export and autophagy is independent of its phosphorylation in Saccharomyces cerevisiae.
the present study sheds light on both the structural and the regulatory functions of Sec16. Our data explain at least in part the mechanism for how Sec16 functions in relation to the COPII coat proteins in the ER.
Title: Insights into structural and regulatory roles of Sec16 in COPII vesicle formation at ER exit sites.
association of Sec24p with Sec16p creates a regulatory complex that retards the GTPase activity of the COPII coat to prevent premature vesicle scission
Title: Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein-membrane adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in COPII vesicle coating	IDA Inferred from Direct Assay more info	PubMed
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in intracellular transport	IEA Inferred from Electronic Annotation more info
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to endoplasmic reticulum exit site	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in ER to Golgi transport vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ER to Golgi transport vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum exit site	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum exit site	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sec16p

NP_015240.1

COPII vesicle coat protein required for ER transport vesicle budding; essential factor in endoplasmic reticulum exit site (ERES) formation, as well as in COPII-mediated ER-to-Golgi traffic; bound to periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

387067..393654

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183899.1 → NP_015240.1 TPA: Sec16p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015240.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3T2, P48415, Q02822

UniProtKB/TrEMBL

A6ZWG6

Conserved Domains (4) summary

PHA03247
Location:680 → 980

PHA03247; large tegument protein UL36; Provisional

pfam12935
Location:291 → 567

Sec16_N; Vesicle coat trafficking protein Sec16 N-terminus

pfam12931
Location:1136 → 1420

Sec16_C; Sec23-binding domain of Sec16

pfam12932
Location:994 → 1093

Sec16; Vesicle coat trafficking protein Sec16 mid-region