PPX1 exopolyphosphatase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PPX1
Official Full Name: exopolyphosphatase
Primary source: SGD:S000001244
Locus tag: YHR201C
See related: AllianceGenome:SGD:S000001244; FungiDB:YHR201C; VEuPathDB:YHR201C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables exopolyphosphatase activity. Involved in polyphosphate catabolic process. Located in cytoplasm. Orthologous to human PRUNE1 (prune exopolyphosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PPX1 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (499950..501143, complement)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ddp1 Cooperates with Ppx1 to Counter a Stress Response Initiated by Nonvacuolar Polyphosphate.
Title: Ddp1 Cooperates with Ppx1 to Counter a Stress Response Initiated by Nonvacuolar Polyphosphate.
PPX1 has restricted role in polyphosphate metabolism.
Title: PPX1 gene overexpression has no influence on polyphosphates in Saccharomyces cerevisiae.
PPX1 and PPN1 genes encoding exopolyphosphatases.
Title: Finding of endopolyphosphatase activity in the yeast Saccharomyces cerevisiae.
Exopolyphosphatase incoded by ppx1 and ppn1 genes do not take part in polyphsphate biosynthesis.
Title: [Polyphosphate consumption and accumulation in Saccharomyces cerevisiae cytosol under inactivation of exopolyphosphatase genes PPX1 and PPN1].
S. cerevisiae possesses a system, which makes it possible to compensate for inactivation of the PPX1 and PPN1 genes encoding exopolyphosphatases of the yeast cells.
Title: Inactivation of PPX1 and PPN1 genes encoding exopolyphosphatases of Saccharomyces cerevisiae does not prevent utilization of polyphosphates as phosphate reserve.
Influence of carbon source on the activity of PPX1.
Title: Polyphosphates and exopolyphosphatases in cytosol and mitochondria of Saccharomyces cerevisiae during growth on glucose or ethanol under phosphate surplus.
describe the high-resolution X-ray structures of yeast PPX1
Title: The crystal structure of the cytosolic exopolyphosphatase from Saccharomyces cerevisiae reveals the basis for substrate specificity.
Exopolyphosphatases in different cell compartments of Saccharomyces cerevisiae.
Title: Inorganic polyphosphates and exopolyphosphatases in different cell compartments of Saccharomyces cerevisiae.
Inactivation of the PPX1 gene (encoding polyphosphate) substantially decreased exopolyphosphatase activities in the cytosol and mitochondrial fractions, the compartments where PPX1 activity was localized.
Title: Inorganic polyphosphates and exopolyphosphatases in cell compartments of the yeast Saccharomyces cerevisiae under inactivation of PPX1 and PPN1 genes.
Dynamics of yeast exopolyphosphatase (scPPX)catalysis reveals significant functional differences between structurally similar scPPX and family II pyrophosphatase.
Title: Kinetic and mutational analyses of the major cytosolic exopolyphosphatase from Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables exopolyphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables exopolyphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables exopolyphosphatase activity	IEA Inferred from Electronic Annotation more info
enables exopolyphosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pyrophosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in polyphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in polyphosphate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: exopolyphosphatase

NP_012071.1

EC 3.6.1.11

Exopolyphosphatase; hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

499950..501143 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179332.1 → NP_012071.1 TPA: exopolyphosphatase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012071.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLF0, P38698

UniProtKB/TrEMBL

A6ZTA8, B3LSW2, C7GRM3, C8ZA02, N1P9I8

Conserved Domains (1) summary

COG1227
Location:27 → 395

PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]