MCO14 4a-hydroxytetrahydrobiopterin dehydratase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MCO14
Official Full Name: 4a-hydroxytetrahydrobiopterin dehydratase
Primary source: SGD:S000001010
Locus tag: YHL018W
See related: AllianceGenome:SGD:S000001010; FungiDB:YHL018W; VEuPathDB:YHL018W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable 4-alpha-hydroxytetrahydrobiopterin dehydratase activity. Predicted to be involved in tetrahydrobiopterin biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia D. Orthologous to several human genes including PCBD1 (pterin-4 alpha-carbinolamine dehydratase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MCO14 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (69708..70070)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in tetrahydrobiopterin biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: 4a-hydroxytetrahydrobiopterin dehydratase

NP_011845.1

EC 4.2.1.96

Putative 4a-hydroxytetrahydrobiopterin dehydratase; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

69708..70070

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179098.1 → NP_011845.1 TPA: 4a-hydroxytetrahydrobiopterin dehydratase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011845.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DKR5, P38744

UniProtKB/TrEMBL

A6ZSN3, B3LSA0, C7GIR8, C8ZA47, G2WF48, N1P2K7

Conserved Domains (1) summary

COG2154
Location:8 → 120

PhhB; Pterin-4a-carbinolamine dehydratase [Coenzyme transport and metabolism]