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    ERG4 delta(24(24(1)))-sterol reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852872, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERG4
    Official Full Name
    delta(24(24(1)))-sterol reductase
    Primary source
    SGD:S000002980
    Locus tag
    YGL012W
    See related
    AllianceGenome:SGD:S000002980; FungiDB:YGL012W; VEuPathDB:YGL012W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables delta24(24-1) sterol reductase activity and delta24-sterol reductase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ERG4 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (472855..474276)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Puf4p Neighboring gene drug-responsive transcription factor PDR1 Neighboring gene proteasome core particle subunit alpha 1 Neighboring gene Mpo1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sterol 24(28) methylene reductase in Saccharomyces cerevisiae. Neal WD, et al. J Bacteriol, 1977 Mar. PMID 14922, Free PMC Article
    2. Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae. Zweytick D, et al. FEBS Lett, 2000 Mar 17. PMID 10722850
    3. Involvement of FgERG4 in ergosterol biosynthesis, vegetative differentiation and virulence in Fusarium graminearum. Liu X, et al. Mol Plant Pathol, 2013 Jan. PMID 22947191, Free PMC Article
    4. The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway. Lai MH, et al. Gene, 1994 Mar 11. PMID 8125337
    5. Inheritance of brewing-relevant phenotypes in constructed Saccharomyces cerevisiae × Saccharomyces eubayanus hybrids. Krogerus K, et al. Microb Cell Fact, 2017 Apr 21. PMID 28431563, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables delta24(24-1) sterol reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables delta24(24-1) sterol reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables delta24(24-1) sterol reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables delta24-sterol reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    delta(24(24(1)))-sterol reductase
    NP_011503.1
    • C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      472855..474276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180877.1 → NP_011503.1  TPA: delta(24(24(1)))-sterol reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011503.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUC5, E9P929, P25340
      UniProtKB/TrEMBL
      A6ZUY1, B3LIM7, C7GK61, G2WE81, N1P5L7
      Conserved Domains (1) summary
      pfam01222
      Location:34 → 473
      ERG4_ERG24; Ergosterol biosynthesis ERG4/ERG24 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25340.2

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