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    EFM5 protein-lysine N-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852884, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EFM5
    Official Full Name
    protein-lysine N-methyltransferase
    Primary source
    SGD:S000003233
    Locus tag
    YGR001C
    See related
    AllianceGenome:SGD:S000003233; FungiDB:YGR001C; VEuPathDB:YGR001C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AML1
    Summary
    Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine trimethylation. Located in cytoplasm. Orthologous to human EEF1AKMT1 (EEF1A lysine methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EFM5 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    3
    Sequence:
    Chromosome: VII; NC_001139.9 (497133..498034, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Erp6p Neighboring gene sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) Neighboring gene Swc4p Neighboring gene cullin CUL3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Circular RNA is expressed across the eukaryotic tree of life. Wang PL, et al. PLoS One, 2014. PMID 24609083, Free PMC Article
    2. A new type of protein lysine methyltransferase trimethylates Lys-79 of elongation factor 1A. Dzialo MC, et al. Biochem Biophys Res Commun, 2014 Dec 12. PMID 25446118, Free PMC Article
    3. Protein Methylation and Translation: Role of Lysine Modification on the Function of Yeast Elongation Factor 1A. White JT, et al. Biochemistry, 2019 Dec 10. PMID 31738538, Free PMC Article
    4. Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human. Hamey JJ, et al. Mol Cell Proteomics, 2016 Jan. PMID 26545399, Free PMC Article
    5. Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus. Kushner DB, et al. Proc Natl Acad Sci U S A, 2003 Dec 23. PMID 14671320, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-lysine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-lysine N-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-lysine trimethylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-lysine trimethylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-lysine N-methyltransferase
    NP_011515.4
    • S-adenosylmethionine-dependent lysine methyltransferase; involved in the trimethylation of eEF1A (Tef1p/Tef2p) at lysine 79; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in budding yeast; expresses a circular RNA; originally misclassified as a N-6-adenine specific DNA methyltransferase based on sequence similarity; both Efm5p and human ortholog N6AMT2 can methylate eEF1a from either species in vitro

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      497133..498034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181130.3 → NP_011515.4  TPA: protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011515.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUD8, P53200
      UniProtKB/TrEMBL
      A6ZUZ3, C8Z8P5, G2WE94, N1P214
      Conserved Domains (1) summary
      pfam10237
      Location:64 → 180
      N6-adenineMlase; Probable N6-adenine methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53200.2

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