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    RPS26A ribosomal 40S subunit protein S26A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPS26A
    Official Full Name
    ribosomal 40S subunit protein S26A
    Primary source
    SGD:S000003157
    Locus tag
    YGL189C
    See related
    AllianceGenome:SGD:S000003157; FungiDB:YGL189C; VEuPathDB:YGL189C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RPS26
    Summary
    Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ribosomal subunit export from nucleus; and ribosome assembly. Part of 90S preribosome. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 10. Orthologous to several human genes including RPS26 (ribosomal protein S26). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPS26A in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (148229..148588, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit VIa Neighboring gene protein phosphatase 2A regulatory subunit CDC55 Neighboring gene uncharacterized protein Neighboring gene cytochrome c oxidase subunit IV

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae homologue of ribosomal protein S26. Wu M, et al. Gene, 1994 Dec 15. PMID 7821815
    2. Ribosomal Protein Rps26 Influences 80S Ribosome Assembly in Saccharomyces cerevisiae. Belyy A, et al. mSphere, 2016 Jan-Feb. PMID 27303706, Free PMC Article
    3. Rps26 directs mRNA-specific translation by recognition of Kozak sequence elements. Ferretti MB, et al. Nat Struct Mol Biol, 2017 Sep. PMID 28759050, Free PMC Article
    4. FLO11 mediated filamentous growth of the yeast Saccharomyces cerevisiae depends on the expression of the ribosomal RPS26 genes. Strittmatter AW, et al. Mol Genet Genomics, 2006 Aug. PMID 16721598
    5. 5´-UTR introns enhance protein expression in the yeast Saccharomyces cerevisiae. Hoshida H, et al. Appl Microbiol Biotechnol, 2017 Jan. PMID 27734122

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These analyses reveal that Rps26 contributes to mRNA-specific translation by recognition of the Kozak sequence in well-translated mRNAs and that Rps26-deficient ribosomes preferentially translate mRNA from select stress-response pathways.
      Title: Rps26 directs mRNA-specific translation by recognition of Kozak sequence elements.
    2. The association of Upf1 with the Rps26 40S subunit is consistent with the notion that this RNA helicase not only triggers rapid decay of nonsense-containing mRNAs, but may also have a role in dissociation of the premature termination complex.
      Title: Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit.
    3. Rps26p is critical for accurate translation of the FLO11 mRNA, and therefore for the dimorphic switch of the bakers yeast from a single cell yeast to an adhesive filamentous growth form.
      Title: FLO11 mediated filamentous growth of the yeast Saccharomyces cerevisiae depends on the expression of the ribosomal RPS26 genes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal subunit export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 40S subunit protein S26A
    NP_011326.1
    • Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26A has a paralog, RPS26B, that arose from the whole genome duplication; human homolog can partially complement an RPS26A, RPS26B double null mutant; mutations in the human gene are associated with Diamond-Blackfan anemia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      148229..148588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181054.1 → NP_011326.1  TPA: ribosomal 40S subunit protein S26A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011326.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2TBN5, D6VTW5, P39938
      UniProtKB/TrEMBL
      A6ZTZ9, B3LHN8, C7GX05, C8Z862, G2WCZ4, G2WDR7, N1P4K9
      Conserved Domains (1) summary
      pfam01283
      Location:1 → 104
      Ribosomal_S26e; Ribosomal protein S26e
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39938.1

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